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Botulinum Toxins MeSH Descriptor Data 2022


MeSH Heading
Botulinum Toxins
Tree Number(s)
D08.811.277.656.300.480.153
D08.811.277.656.675.374.153
D12.776.097.156
D23.946.123.179
Unique ID
D001905
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D001905
Annotation
/antag permitted but consider also BOTULINUM ANTITOXIN
Scope Note
Toxic proteins produced from the species CLOSTRIDIUM BOTULINUM. The toxins are synthesized as a single peptide chain which is processed into a mature protein consisting of a heavy chain and light chain joined via a disulfide bond. The botulinum toxin light chain is a zinc-dependent protease which is released from the heavy chain upon ENDOCYTOSIS into PRESYNAPTIC NERVE ENDINGS. Once inside the cell the botulinum toxin light chain cleaves specific SNARE proteins which are essential for secretion of ACETYLCHOLINE by SYNAPTIC VESICLES. This inhibition of acetylcholine release results in muscular PARALYSIS.
Entry Term(s)
Botulin
Botulinum Neurotoxin
Botulinum Neurotoxins
Botulinum Toxin
Clostridium botulinum Toxins
Pharm Action
Neurotoxins
Acetylcholine Release Inhibitors
Registry Number
EC 3.4.24.69
Previous Indexing
Clostridium Botulinum (1966-1968)
Toxins (1966-1968)
See Also
Botulism
Public MeSH Note
78; was BOTULINUM TOXIN 1972-77
Online Note
use BOTULINUM TOXINS to search BOTULINUM TOXIN 1969-77 (as Prov 1969-71)
History Note
78; was BOTULINUM TOXIN 1969-77 (Prov 1969-71)
Date Established
1972/01/01
Date of Entry
1999/01/01
Revision Date
2020/05/27
Botulinum Toxins Preferred
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