MeSH Browser

MeSH Heading: Botulinum Toxins
Tree Number(s): D08.811.277.656.300.480.153; D08.811.277.656.675.374.153; D12.776.097.156; D23.946.123.179
Unique ID: D001905
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D001905
Annotation: /antag permitted but consider also BOTULINUM ANTITOXIN
Scope Note: Toxic proteins produced from the species CLOSTRIDIUM BOTULINUM. The toxins are synthesized as a single peptide chain which is processed into a mature protein consisting of a heavy chain and light chain joined via a disulfide bond. The botulinum toxin light chain is a zinc-dependent protease which is released from the heavy chain upon ENDOCYTOSIS into PRESYNAPTIC NERVE ENDINGS. Once inside the cell the botulinum toxin light chain cleaves specific SNARE proteins which are essential for secretion of ACETYLCHOLINE by SYNAPTIC VESICLES. This inhibition of acetylcholine release results in muscular PARALYSIS.
Entry Term(s): Botulin; Botulinum Neurotoxin; Botulinum Neurotoxins; Botulinum Toxin; Clostridium botulinum Toxins
Pharm Action: Neurotoxins
Acetylcholine Release Inhibitors
Previous Indexing: Clostridium Botulinum (1966-1968); Toxins (1966-1968)
See Also: Botulism
Public MeSH Note: 78; was BOTULINUM TOXIN 1972-77
Online Note: use BOTULINUM TOXINS to search BOTULINUM TOXIN 1969-77 (as Prov 1969-71)
History Note: 78; was BOTULINUM TOXIN 1969-77 (Prov 1969-71)
Date Established: 1972/01/01
Date of Entry: 1999/01/01
Revision Date: 2020/05/27

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0002844
Scope Note: Toxic proteins produced from the species CLOSTRIDIUM BOTULINUM. The toxins are synthesized as a single peptide chain which is processed into a mature protein consisting of a heavy chain and light chain joined via a disulfide bond. The botulinum toxin light chain is a zinc-dependent protease which is released from the heavy chain upon ENDOCYTOSIS into PRESYNAPTIC NERVE ENDINGS. Once inside the cell the botulinum toxin light chain cleaves specific SNARE proteins which are essential for secretion of ACETYLCHOLINE by SYNAPTIC VESICLES. This inhibition of acetylcholine release results in muscular PARALYSIS.
Terms: Botulinum Toxins Preferred Term
Term UI T005421
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1969); Botulinum Neurotoxin
Term UI T001006299
Date01/28/2020
LexicalTag NON
ThesaurusID NLM (2021); Botulin
Term UI T005419
Date04/14/1977
LexicalTag NON
ThesaurusID UNK (19XX); Botulinum Toxin
Term UI T005420
Date04/21/1977
LexicalTag NON
ThesaurusID UNK (19XX); Clostridium botulinum Toxins
Term UI T005422
Date06/17/1985
LexicalTag NON
ThesaurusID UNK (19XX); Botulinum Neurotoxins
Term UI T001006298
Date01/28/2020
LexicalTag NON
ThesaurusID NLM (2021)

Botulinum Toxins MeSH Descriptor Data 2025