Matrix Metalloproteinases MeSH Descriptor Data 2025

MeSH Heading: Matrix Metalloproteinases
Tree Number(s): D08.811.277.656.300.480.525; D08.811.277.656.675.374.525
Unique ID: D020782
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D020782
Annotation: general or unspecified; prefer specifics
Scope Note: A family of zinc-dependent metalloendopeptidases that is involved in the degradation of EXTRACELLULAR MATRIX components.
Entry Term(s): MMP; MMPs; Matrix Metalloproteinase
Previous Indexing: Metalloendopeptidases (1988-1999)
Public MeSH Note: 2000
History Note: 2000
Entry Combination: antagonists & inhibitors:Matrix Metalloproteinase Inhibitors
Date Established: 2000/01/01
Date of Entry: 1999/11/08
Revision Date: 2020/05/27

Entry Combination: antagonists & inhibitors:Matrix Metalloproteinase Inhibitors
Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Hydrolases [D08.811.277]
    - Peptide Hydrolases [D08.811.277.656]
      - Endopeptidases [D08.811.277.656.300]
        
        Metalloendopeptidases [D08.811.277.656.300.480]
        
        Botulinum Toxins [D08.811.277.656.300.480.153]
        
        Collagenases [D08.811.277.656.300.480.205]
        
        Endothelin-Converting Enzymes [D08.811.277.656.300.480.229]
        
        Gelatinases [D08.811.277.656.300.480.252]
        
        Insulysin [D08.811.277.656.300.480.300]
        
        Lysostaphin [D08.811.277.656.300.480.452]
        
        Matrix Metalloproteinases [D08.811.277.656.300.480.525]
        
        Matrix Metalloproteinases, Membrane-Associated [D08.811.277.656.300.480.525.300]
        
        Matrix Metalloproteinases, Secreted [D08.811.277.656.300.480.525.700]
        
        Mitochondrial Processing Peptidase [D08.811.277.656.300.480.563]
        
        Neprilysin [D08.811.277.656.300.480.600]
        
        PHEX Phosphate Regulating Neutral Endopeptidase [D08.811.277.656.300.480.616]
        
        Pregnancy-Associated Plasma Protein-A [D08.811.277.656.300.480.632]
        
        Procollagen N-Endopeptidase [D08.811.277.656.300.480.664]
        
        Pronase [D08.811.277.656.300.480.680]
        
        Thermolysin [D08.811.277.656.300.480.827]

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Hydrolases [D08.811.277]
    - Peptide Hydrolases [D08.811.277.656]
      - Metalloproteases [D08.811.277.656.675]
        
        Metalloendopeptidases [D08.811.277.656.675.374]
        
        ADAM Proteins [D08.811.277.656.675.374.102]
        
        Botulinum Toxins [D08.811.277.656.675.374.153]
        
        Collagenases [D08.811.277.656.675.374.205]
        
        Endothelin-Converting Enzymes [D08.811.277.656.675.374.229]
        
        Gelatinases [D08.811.277.656.675.374.252]
        
        Insulysin [D08.811.277.656.675.374.300]
        
        Lysostaphin [D08.811.277.656.675.374.452]
        
        Matrix Metalloproteinases [D08.811.277.656.675.374.525]
        
        Matrix Metalloproteinases, Membrane-Associated [D08.811.277.656.675.374.525.300]
        
        Matrix Metalloproteinases, Secreted [D08.811.277.656.675.374.525.700]
        
        Mitochondrial Processing Peptidase [D08.811.277.656.675.374.563]
        
        Neprilysin [D08.811.277.656.675.374.600]
        
        PHEX Phosphate Regulating Neutral Endopeptidase [D08.811.277.656.675.374.616]
        
        Pregnancy-Associated Plasma Protein-A [D08.811.277.656.675.374.632]
        
        Procollagen N-Endopeptidase [D08.811.277.656.675.374.664]
        
        Pronase [D08.811.277.656.675.374.680]
        
        Thermolysin [D08.811.277.656.675.374.827]

Matrix Metalloproteinases Preferred

Concept UI: M0328197
Scope Note: A family of zinc-dependent metalloendopeptidases that is involved in the degradation of EXTRACELLULAR MATRIX components.
Terms: Matrix Metalloproteinases Preferred Term
Term UI T358197
Date10/12/1999
LexicalTag NON
ThesaurusID NLM (2000); MMP
Term UI T000996809
Date11/15/2019
LexicalTag NON
ThesaurusID NLM (2021); MMPs
Term UI T363568
Date10/12/1999
LexicalTag ABB
ThesaurusID NLM (2000); Matrix Metalloproteinase
Term UI T000996103
Date11/13/2019
LexicalTag NON
ThesaurusID NLM (2021)

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