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Neprilysin MeSH Descriptor Data 2023


MeSH Heading
Neprilysin
Tree Number(s)
D08.811.277.656.300.480.600
D08.811.277.656.675.374.600
D23.050.285.550
D23.101.140.500
Unique ID
D015260
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D015260
Scope Note
Enzyme that is a major constituent of kidney brush-border membranes and is also present to a lesser degree in the brain and other tissues. It preferentially catalyzes cleavage at the amino group of hydrophobic residues of the B-chain of insulin as well as opioid peptides and other biologically active peptides. The enzyme is inhibited primarily by EDTA, phosphoramidon, and thiorphan and is reactivated by zinc. Neprilysin is identical to common acute lymphoblastic leukemia antigen (CALLA Antigen), an important marker in the diagnosis of human acute lymphocytic leukemia. There is no relationship with CALLA PLANT.
Entry Term(s)
Antigens, CD10
Antigens, Leukemia, Common Acute Lymphoblastic
Atriopeptidase
CALLA Antigen
CD10 Antigen
CD10 Antigens
Common Acute Lymphoblastic Leukemia Antigens
Endopeptidase-24.11
Enkephalin Dipeptidyl Carboxypeptidase
Enkephalinase
Enkephalinase-24.11
Kidney-Brush-Border Neutral Proteinase
Membrane Metallo-Endopeptidase
Neutral Endopeptidase
Neutral Endopeptidase 24.11
Thermolysin-Like Metalloendopeptidase
YGG-Forming Enzyme
Registry Number
EC 3.4.24.11
Previous Indexing
Metalloproteinases (1987-1988)
Peptide Peptidohydrolases (1966-1987)
Public MeSH Note
1997; was MEMBRANE METALLO-ENDOPEPTIDASE 1989-96; COMMON ACUTE LYMPHOBLASTIC LEUKEMIA ANTIGENS was indexed under ANTIGENS, NEOPLASM & ANTIGENS, DIFFERENTIATION 1983-92; for CALLA ANTIGEN see CALLA 1993-2002
Online Note
use NEPRILYSIN (NM) to search COMMON ACUTE LYMPHOBLASTIC LEUKEMIA ANTIGENS 1983-92
History Note
1997; was MEMBRANE METALLO-ENDOPEPTIDASE 1989-96; COMMON ACUTE LYMPHOBLASTIC LEUKEMIA ANTIGENS was COMMON ACUTE LYMPHOBLASTIC LEUKEMIA ANTIGENS (NM) 1983-92
Date Established
1989/01/01
Date of Entry
1988/05/18
Revision Date
2017/05/24
Neprilysin Preferred
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