Endothelin-Converting Enzymes MeSH Descriptor Data 2025

MeSH Heading: Endothelin-Converting Enzymes
Tree Number(s): D08.811.277.656.074.500.270; D08.811.277.656.300.048.270; D08.811.277.656.300.480.229; D08.811.277.656.675.374.229
Unique ID: D000072396
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000072396
Scope Note: Metalloendopeptidases which convert BIG ENDOTHELIN to ENDOTHELIN-1.
Entry Term(s): ECE-1beta; Endothelin Converting Enzyme; Endothelin Converting Enzyme-1a; Endothelin-Converting Enzyme; Endothelin-Converting Enzyme 1; Endothelin-Converting Enzyme 2; Endothelin-Converting Enzyme II; Endothelin-Converting Enzyme-1b; Endothelin-Converting Metalloprotease 2; Metalloprotease ECE-2
Public MeSH Note: 2017; ENDOTHELIN CONVERTING ENZYMES was indexed under METALLOENDOPEPTIDASES and ASPARTIC ACID ENDOPEPTIDASES 1991-2016; and under PEPTIDE PEPTIDOHYDROLASES 1990-1991
History Note: 2017 (1990)
Date Established: 2017/01/01
Date of Entry: 2016/07/08
Revision Date: 2016/05/27

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Hydrolases [D08.811.277]
    - Peptide Hydrolases [D08.811.277.656]
      - Aspartic Acid Proteases [D08.811.277.656.074]
        
        Aspartic Acid Endopeptidases [D08.811.277.656.074.500]
        
        Cathepsin D [D08.811.277.656.074.500.180]
        
        Cathepsin E [D08.811.277.656.074.500.185]
        
        Chymosin [D08.811.277.656.074.500.200]
        
        Endothelin-Converting Enzymes [D08.811.277.656.074.500.270]
        
        HIV Protease [D08.811.277.656.074.500.340]
        
        Pepsin A [D08.811.277.656.074.500.700]
        
        Renin [D08.811.277.656.074.500.780]
        
        Secreted Aspartic Proteases [D08.811.277.656.074.500.890]

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Hydrolases [D08.811.277]
    - Peptide Hydrolases [D08.811.277.656]
      - Endopeptidases [D08.811.277.656.300]
        
        Aspartic Acid Endopeptidases [D08.811.277.656.300.048]
        
        Cathepsin D [D08.811.277.656.300.048.180]
        
        Cathepsin E [D08.811.277.656.300.048.185]
        
        Chymosin [D08.811.277.656.300.048.200]
        
        Endothelin-Converting Enzymes [D08.811.277.656.300.048.270]
        
        HIV Protease [D08.811.277.656.300.048.340]
        
        Pepsin A [D08.811.277.656.300.048.700]
        
        Renin [D08.811.277.656.300.048.780]

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Hydrolases [D08.811.277]
    - Peptide Hydrolases [D08.811.277.656]
      - Endopeptidases [D08.811.277.656.300]
        
        Metalloendopeptidases [D08.811.277.656.300.480]
        
        Botulinum Toxins [D08.811.277.656.300.480.153]
        
        Collagenases [D08.811.277.656.300.480.205]
        
        Endothelin-Converting Enzymes [D08.811.277.656.300.480.229]
        
        Gelatinases [D08.811.277.656.300.480.252]
        
        Insulysin [D08.811.277.656.300.480.300]
        
        Lysostaphin [D08.811.277.656.300.480.452]
        
        Matrix Metalloproteinases [D08.811.277.656.300.480.525]
        
        Mitochondrial Processing Peptidase [D08.811.277.656.300.480.563]
        
        Neprilysin [D08.811.277.656.300.480.600]
        
        PHEX Phosphate Regulating Neutral Endopeptidase [D08.811.277.656.300.480.616]
        
        Pregnancy-Associated Plasma Protein-A [D08.811.277.656.300.480.632]
        
        Procollagen N-Endopeptidase [D08.811.277.656.300.480.664]
        
        Pronase [D08.811.277.656.300.480.680]
        
        Thermolysin [D08.811.277.656.300.480.827]

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Hydrolases [D08.811.277]
    - Peptide Hydrolases [D08.811.277.656]
      - Metalloproteases [D08.811.277.656.675]
        
        Metalloendopeptidases [D08.811.277.656.675.374]
        
        ADAM Proteins [D08.811.277.656.675.374.102]
        
        Botulinum Toxins [D08.811.277.656.675.374.153]
        
        Collagenases [D08.811.277.656.675.374.205]
        
        Endothelin-Converting Enzymes [D08.811.277.656.675.374.229]
        
        Gelatinases [D08.811.277.656.675.374.252]
        
        Insulysin [D08.811.277.656.675.374.300]
        
        Lysostaphin [D08.811.277.656.675.374.452]
        
        Matrix Metalloproteinases [D08.811.277.656.675.374.525]
        
        Mitochondrial Processing Peptidase [D08.811.277.656.675.374.563]
        
        Neprilysin [D08.811.277.656.675.374.600]
        
        PHEX Phosphate Regulating Neutral Endopeptidase [D08.811.277.656.675.374.616]
        
        Pregnancy-Associated Plasma Protein-A [D08.811.277.656.675.374.632]
        
        Procollagen N-Endopeptidase [D08.811.277.656.675.374.664]
        
        Pronase [D08.811.277.656.675.374.680]
        
        Thermolysin [D08.811.277.656.675.374.827]

Endothelin-Converting Enzymes Preferred

Endothelin Converting Enzyme-1a Narrower

Endothelin-Converting Enzyme-1b Narrower

Endothelin-Converting Enzyme 2 Narrower

Concept UI: M0482654
Scope Note: An integral membrane metalloendodpeptidase which converts BIG ENDOTHELIN to ENDOTHELIN-1 through hydrolysis of the TRYPTOPHAN (21)-VALINE (22) bond . It is also involved in the processing of various neuroendocrine peptides and may have methyltransferase activity.
Terms: Endothelin-Converting Enzyme 2 Preferred Term
Term UI T000899433
Date04/21/2016
LexicalTag NON
ThesaurusID NLM (1990); Endothelin-Converting Enzyme II
Term UI T000899435
Date04/21/2016
LexicalTag NON
ThesaurusID NLM (2001); Endothelin-Converting Metalloprotease 2
Term UI T000899436
Date04/21/2016
LexicalTag NON
ThesaurusID NLM (1990); Metalloprotease ECE-2
Term UI T000899437
Date04/21/2016
LexicalTag ABX
ThesaurusID NLM (1990)

Endothelin-Converting Enzyme 1 Narrower

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