MeSH Browser

MeSH Heading: Endothelin-1
Tree Number(s): D12.644.276.400.225; D12.776.467.400.225; D23.529.400.225
Unique ID: D019332
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D019332
Annotation: /drug eff permitted
Scope Note: A 21-amino acid peptide produced in a variety of tissues including endothelial and vascular smooth-muscle cells, neurons and astrocytes in the central nervous system, and endometrial cells. It acts as a modulator of vasomotor tone, cell proliferation, and hormone production. (N Eng J Med 1995;333(6):356-63)
Entry Term(s): Big Endothelin; Big Endothelin-1; Endothelin Type 1; Endothelin, Big; Preproendothelin; Preproendothelin-1; Proendothelin (1-38); Proendothelin-1 Precursor
Related Numbers: 114540-95-3; 122462-75-3
Previous Indexing: Endothelins (1991-1996)
Public MeSH Note: 2004; see ENDOTHELINS 1991-1996; BIG ENDOTHELIN was indexed under ENDTHELINS & PROTEIN PRECUSORS 1991-2003; under PEPTIDES 1990; PREPROENDOTHELIN was indexed under ENDOTHELINS & PROTEIN PRECUSORS 1989-2003
History Note: 2004(1997); use ENDOTHELINS 1991-96; for BIG ENDOTHELIN use ENDOTHELIN-1 (NM) 1990-2003; for PREPROENDOLTHELIN use ENDOTHELINS-1 (NM) 1989-2003
Date Established: 1997/01/01
Date of Entry: 1996/06/10
Revision Date: 2015/06/26

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analogs & derivatives (AA)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

urine (UR)

Concept UI: M0174536
Scope Note: A 38 amino acid form of endothelin-1 that results from alternative processing of proendothelin-1.
Terms: Proendothelin (1-38) Preferred Term
Term UI T204540
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2004); Big Endothelin-1
Term UI T204538
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2004); Endothelin, Big
Term UI T204539
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2004); Big Endothelin
Term UI T204541
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2004)

Endothelin-1 MeSH Descriptor Data 2025