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Endothelin-1 MeSH Descriptor Data 2023


MeSH Heading
Endothelin-1
Tree Number(s)
D12.644.276.400.225
D12.776.467.400.225
D23.529.400.225
Unique ID
D019332
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D019332
Annotation
/drug eff permitted
Scope Note
A 21-amino acid peptide produced in a variety of tissues including endothelial and vascular smooth-muscle cells, neurons and astrocytes in the central nervous system, and endometrial cells. It acts as a modulator of vasomotor tone, cell proliferation, and hormone production. (N Eng J Med 1995;333(6):356-63)
Entry Term(s)
Big Endothelin
Big Endothelin-1
Endothelin Type 1
Endothelin, Big
Preproendothelin
Preproendothelin-1
Proendothelin (1-38)
Proendothelin-1 Precursor
Registry Number
0
Related Numbers
114540-95-3
122462-75-3
Previous Indexing
Endothelins (1991-1996)
Public MeSH Note
2004; see ENDOTHELINS 1991-1996; BIG ENDOTHELIN was indexed under ENDTHELINS & PROTEIN PRECUSORS 1991-2003; under PEPTIDES 1990; PREPROENDOTHELIN was indexed under ENDOTHELINS & PROTEIN PRECUSORS 1989-2003
History Note
2004(1997); use ENDOTHELINS 1991-96; for BIG ENDOTHELIN use ENDOTHELIN-1 (NM) 1990-2003; for PREPROENDOLTHELIN use ENDOTHELINS-1 (NM) 1989-2003
Date Established
1997/01/01
Date of Entry
1996/06/10
Revision Date
2015/06/26
Endothelin-1 Preferred
Proendothelin (1-38) Narrower
Preproendothelin-1 Narrower
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