MeSH Browser

MeSH Heading: Endothelins
Tree Number(s): D12.644.276.400; D12.776.467.400; D23.529.400
Unique ID: D016232
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D016232
Annotation: general or unspecified; prefer specifics
Scope Note: 21-Amino-acid peptides produced by vascular endothelial cells and functioning as potent vasoconstrictors. The endothelin family consists of three members, ENDOTHELIN-1; ENDOTHELIN-2; and ENDOTHELIN-3. All three peptides contain 21 amino acids, but vary in amino acid composition. The three peptides produce vasoconstrictor and pressor responses in various parts of the body. However, the quantitative profiles of the pharmacological activities are considerably different among the three isopeptides.
Entry Term(s): Endothelin; Endothelium-Derived Vasoconstrictor Factors
Previous Indexing: Peptides (1966-1990)
See Also: Receptors, Endothelin
Public MeSH Note: 91
History Note: 91
Date Established: 1991/01/01
Date of Entry: 1990/06/28
Revision Date: 2006/07/05

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

urine (UR)

Concept UI: M0024788
Scope Note: 21-Amino-acid peptides produced by vascular endothelial cells and functioning as potent vasoconstrictors. The endothelin family consists of three members, ENDOTHELIN-1; ENDOTHELIN-2; and ENDOTHELIN-3. All three peptides contain 21 amino acids, but vary in amino acid composition. The three peptides produce vasoconstrictor and pressor responses in various parts of the body. However, the quantitative profiles of the pharmacological activities are considerably different among the three isopeptides.
Terms: Endothelins Preferred Term
Term UI T048330
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1991); Endothelin
Term UI T048329
Date03/10/1990
LexicalTag NON
ThesaurusID NLM (1991); Endothelium-Derived Vasoconstrictor Factors
Term UI T048331
Date03/10/1990
LexicalTag NON
ThesaurusID NLM (1991)

Endothelins MeSH Descriptor Data 2025