MeSH Browser

MeSH Heading: Myocilin
Tree Number(s): D12.644.276.856; D12.776.306.458; D12.776.467.851; D23.529.836
Unique ID: D000099179
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000099179
Scope Note: A secreted glycoprotein that controls activation of signaling pathways in adjacent cells (PARACRINE COMMUNICATION) for processes that include CELL ADHESION; CELL MIGRATION; and organization of the CYTOSKELETON. It is primarily expressed in the RETINA and variants in the myocillin gene cause GLAUCOMA 1, OPEN ANGLE, A.
Entry Term(s): GLC1A Protein; MYOC Protein; TIGR Protein; Trabecular Meshwork-induced Glucocorticoid Response Protein
Public MeSH Note: 2026; see TRABECULAR MESHWORK-INDUCED GLUCOCORTICOID RESPONSE PROTEIN (NM) 1997-2025; MYOCILIN was indexed under CYTOSKELETAL PROTEINS, EYE PROTEINS, and GLYCOPROTEINS 1997-2025.
History Note: 2026 (1997); use TRABECULAR MESHWORK-INDUCED GLUCOCORTICOID RESPONSE PROTEIN (NM) 1997-2025
Date Introduced: 2026/01/01
Last Updated: 2026/01/01

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M000768868
Scope Note: A secreted glycoprotein that controls activation of signaling pathways in adjacent cells (PARACRINE COMMUNICATION) for processes that include CELL ADHESION; CELL MIGRATION; and organization of the CYTOSKELETON. It is primarily expressed in the RETINA and variants in the myocillin gene cause GLAUCOMA 1, OPEN ANGLE, A.
Terms: Myocilin Preferred Term
Term UI T001147657
Date03/25/2025
LexicalTag NON
ThesaurusID NLM (1997); GLC1A Protein
Term UI T001147658
Date03/25/2025
LexicalTag ABX
ThesaurusID NLM (2005); MYOC Protein
Term UI T001147659
Date03/25/2025
LexicalTag ABX
ThesaurusID NLM (2005); TIGR Protein
Term UI T001147660
Date03/25/2025
LexicalTag ABX
ThesaurusID NLM (1997); Trabecular Meshwork-induced Glucocorticoid Response Protein
Term UI T001147661
Date03/25/2025
LexicalTag NON
ThesaurusID NLM (1997)

Myocilin MeSH Descriptor Data 2026