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A developmentally regulated, HEPARIN-binding secreted growth factor homologous to pleiotrophin (PTN). It regulates cell proliferation through its interaction with ANAPLASTIC LYMPHOMA KINASE (ALK) and is involved in the formation of NEOINTIMA following arterial injury.
Entry Term(s)
Amphiregulin-Associated Protein
Cytokine MK
Registry Numbers
137497-38-2
Public MeSH Note
2019; MIDKINE was indexed under CYTOKINES 2005-2018; and under CARRIER PROTEINS 1991-2004
A developmentally regulated, HEPARIN-binding secreted growth factor homologous to pleiotrophin (PTN). It regulates cell proliferation through its interaction with ANAPLASTIC LYMPHOMA KINASE (ALK) and is involved in the formation of NEOINTIMA following arterial injury.