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Semaphorins MeSH Descriptor Data 2023


MeSH Heading
Semaphorins
Tree Number(s)
D12.644.276.923
D12.776.467.923
D23.529.923
Unique ID
D039961
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D039961
Scope Note
A family of proteins that mediate AXONAL GUIDANCE. Semaphorins act as repulsive cues for neuronal GROWTH CONES and bind to receptors on their filopodia. At least 20 different molecules have been described and divided into eight classes based on domain organization and species of origin. Classes 1 and 2 are invertebrate, classes 3-7 are vertebrate, and class V are viral. Semaphorins may be secreted (classes 2, 3, and V), transmembrane (classes 1, 4, 5, and 6), or membrane-anchored (class 7). All semaphorins possess a common 500-amino acid extracellular domain which is critical for receptor binding and specificity, and is also found in plexins and scatter factor receptors. Their C termini are class-specific and may contain additional sequence motifs.
Entry Term(s)
Class 1 Semaphorins
Class 2 Semaphorins
Class 3 Semaphorins
Class 4 Semaphorins
Class 5 Semaphorins
Class 6 Semaphorins
Class 7 Semaphorins
Class V Semaphorins
Sema 1
Semaphorin
Semaphorin-1
Semaphorin-2
Semaphorin-3
Semaphorin-4
Semaphorin-5
Semaphorin-6
Semaphorin-7
Semaphorin-V
Registry Number
0
Public MeSH Note
2003; SEMA 1 & SEMAPHORIN-1 was indexed under CELL ADHESION MOLECULES, NEURONAL 1994-2002
History Note
2003; for SEMA 1 & SEMAPHORIN-1 use SEMAPHORIN 1A, GRASSHOPPER (NM) 1994-2002
Date Established
2003/01/01
Date of Entry
2002/07/03
Revision Date
2016/02/26
Semaphorins Preferred
Class 2 Semaphorins Narrower
Class 3 Semaphorins Narrower
Class V Semaphorins Narrower
Class 5 Semaphorins Narrower
Class 6 Semaphorins Narrower
Class 7 Semaphorins Narrower
Class 1 Semaphorins Narrower
Class 4 Semaphorins Narrower
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