MeSH Browser

MeSH Heading: Progranulins
Tree Number(s): D06.472.699.682; D12.644.276.917; D12.776.467.917; D12.776.811.703; D23.529.917
Unique ID: D000077153
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000077153
Scope Note: Cysteine-rich, precursor glycoproteins encoded by the granulin gene (GRN). They contain granulin-repeats separated by linker sequences that are cleaved by a variety of proteases to release the individual GRANULIN PEPTIDES. The mammalian progranulin is composed of a half-granulin repeat followed by 7 granulin repeats. The mammalian GRANULINS are named PARAGRANULIN and granulin 1-7 for their order in the progranulin propeptide. Progranulin has growth-factor like effects and is expressed over a broad range of tissues. Under-expression of progranulin is linked to neurodegenerative diseases including FRONTOTEMPORAL DEMENTIA and NEURONAL CEROID LIPOFUSCINOSIS, while over-expression is linked to metabolic diseases including OBESITY, and INSULIN RESISTANCE.
Entry Term(s): Acrogranin; Granulin Precursor; Granulin Precursor Protein; PC Cell-Derived Growth Factor; Proepithelin; Progranulin
Related Numbers: 134710-81-9
Previous Indexing: Intercellular Signaling Peptides and Proteins (1999-2018)
Public MeSH Note: 2019; GRANULIN PRECURSOR PROTEIN was indexed under INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS 2004-2018 and VIRAL PROTEINS1992-2003
History Note: 2019
Date Established: 2019/01/01
Date of Entry: 2018/07/09
Revision Date: 2019/07/05

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analogs & derivatives (AA)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

urine (UR)

Hormones, Hormone Substitutes, and Hormone Antagonists [D06]
- Hormones [D06.472]
  - Peptide Hormones [D06.472.699]

Amino Acids, Peptides, and Proteins [D12]
- Peptides [D12.644]
  - Intercellular Signaling Peptides and Proteins [D12.644.276]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Intercellular Signaling Peptides and Proteins [D12.776.467]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Protein Precursors [D12.776.811]

Biological Factors [D23]
- Intercellular Signaling Peptides and Proteins [D23.529]

Progranulins Preferred

Concept UI: M000639461
Related Numbers: 134710-81-9
Scope Note: Cysteine-rich, precursor glycoproteins encoded by the granulin gene (GRN). They contain granulin-repeats separated by linker sequences that are cleaved by a variety of proteases to release the individual GRANULIN PEPTIDES. The mammalian progranulin is composed of a half-granulin repeat followed by 7 granulin repeats. The mammalian GRANULINS are named PARAGRANULIN and granulin 1-7 for their order in the progranulin propeptide. Progranulin has growth-factor like effects and is expressed over a broad range of tissues. Under-expression of progranulin is linked to neurodegenerative diseases including FRONTOTEMPORAL DEMENTIA and NEURONAL CEROID LIPOFUSCINOSIS, while over-expression is linked to metabolic diseases including OBESITY, and INSULIN RESISTANCE.
Terms: Progranulins Preferred Term
Term UI T000937049
Date12/01/2017
LexicalTag NON
ThesaurusID NLM (2019); Acrogranin
Term UI T000937055
Date12/01/2017
LexicalTag NON
ThesaurusID NLM (2019); Proepithelin
Term UI T000937056
Date12/01/2017
LexicalTag NON
ThesaurusID NLM (2019); Progranulin
Term UI T000937061
Date12/01/2017
LexicalTag NON
ThesaurusID NLM (2019); Granulin Precursor Protein
Term UI T000937077
Date12/01/2017
LexicalTag NON
ThesaurusID NLM (2019); PC Cell-Derived Growth Factor
Term UI T000937078
Date12/01/2017
LexicalTag NON
ThesaurusID NLM (2019); Granulin Precursor
Term UI T000937079
Date12/01/2017
LexicalTag NON
ThesaurusID NLM (2019)

Progranulins MeSH Descriptor Data 2025