MeSH Browser

MeSH Heading: Granulins
Tree Number(s): D06.472.699.682.500; D12.644.276.917.500; D12.776.467.917.500; D23.529.917.500
Unique ID: D000077155
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000077155
Annotation: do not confuse with the viral protein GRANULIN MATRIX PROTEINS see OCCLUSION BODY MATRIX PROTEINS
Scope Note: Small, cysteine-rich peptides generated by the proteolytic cleavage of progranulin. Granulin peptides are each composed of a granulin-motif, while paragranulin is composed of a half-granulin motif. The mammalian granulins are named granulin 1-7 for their sequence order in the progranulin propeptide, and are alternately named granulin G, F, B, A, C, D, and E; or epithelin 7, 6, 2, 1, 3, 4, and 5, i.e. granulin 1 aka granulin G aka epithelin 7, etc.
Entry Term(s): Epithelin; Epithelin 1; Epithelin 2; Epithelin 3; Epithelin 4; Epithelin 5; Epithelin-1; Epithelin-2; Epithelin2; Epithelins; Granulin; Granulin (123-179); Granulin (206-261); Granulin 1; Granulin 2; Granulin 3; Granulin 4; Granulin 5; Granulin 6; Granulin 7; Granulin A; Granulin B; Granulin C; Granulin D; Granulin E; Granulin F; Granulin G; Granulin Peptide (281-336); Granulin Peptide (58 -113); Granulin Peptides; Granulin-3; Granulin3; Paragranulin
Registry Numbers: 0; 148708-92-3
Related Numbers: 148708-92-3
Previous Indexing: Intercellular Signaling Peptides and Proteins (1992-2018)
Public MeSH Note: 2019
History Note: 2019
Date Established: 2019/01/01
Date of Entry: 2018/07/09
Revision Date: 2020/05/27

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analogs & derivatives (AA)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

urine (UR)

Hormones, Hormone Substitutes, and Hormone Antagonists [D06]
- Hormones [D06.472]
  - Peptide Hormones [D06.472.699]
    - Progranulins [D06.472.699.682]
      - Granulins [D06.472.699.682.500]

Amino Acids, Peptides, and Proteins [D12]
- Peptides [D12.644]
  - Intercellular Signaling Peptides and Proteins [D12.644.276]
    - Progranulins [D12.644.276.917]
      - Granulins [D12.644.276.917.500]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Intercellular Signaling Peptides and Proteins [D12.776.467]
    - Progranulins [D12.776.467.917]
      - Granulins [D12.776.467.917.500]

Biological Factors [D23]
- Intercellular Signaling Peptides and Proteins [D23.529]
  - Progranulins [D23.529.917]
    - Granulins [D23.529.917.500]

Granulins Preferred

Concept UI: M000639465
Registry Numbers: 0
Related Numbers: 148708-92-3
Scope Note: Small, cysteine-rich peptides generated by the proteolytic cleavage of progranulin. Granulin peptides are each composed of a granulin-motif, while paragranulin is composed of a half-granulin motif. The mammalian granulins are named granulin 1-7 for their sequence order in the progranulin propeptide, and are alternately named granulin G, F, B, A, C, D, and E; or epithelin 7, 6, 2, 1, 3, 4, and 5, i.e. granulin 1 aka granulin G aka epithelin 7, etc.
Terms: Granulins Preferred Term
Term UI T000937080
Date12/01/2017
LexicalTag NON
ThesaurusID NLM (2019); Granulin
Term UI T001004682
Date01/06/2020
LexicalTag NON
ThesaurusID NLM (2021); Epithelin
Term UI T001004683
Date01/06/2020
LexicalTag NON
ThesaurusID NLM (2021); Epithelins
Term UI T000937063
Date12/01/2017
LexicalTag NON
ThesaurusID NLM (2019); Granulin Peptides
Term UI T000937700
Date12/13/2017
LexicalTag NON
ThesaurusID NLM (2019)

Granulin 3 Narrower

Concept UI: M0181725
Registry Numbers: 0
Scope Note: Granulin from the third granulin repeat of the proteolytically processed mammalian progranulin protein . It is also called Granulin B.
Terms: Granulin 3 Preferred Term
Term UI T000938322
Date12/27/2017
LexicalTag NON
ThesaurusID NLM (2019); Epithelin-2
Term UI T000938316
Date12/27/2017
LexicalTag NON
ThesaurusID NLM (2019); Granulin (206-261)
Term UI T000938317
Date12/27/2017
LexicalTag NON
ThesaurusID NLM (2019); Epithelin2
Term UI T000938318
Date12/27/2017
LexicalTag NON
ThesaurusID NLM (2019); Epithelin 2
Term UI T000938315
Date12/27/2017
LexicalTag NON
ThesaurusID NLM (2019); Granulin-3
Term UI T000938320
Date12/27/2017
LexicalTag NON
ThesaurusID NLM (2019); Granulin3
Term UI T000938321
Date12/27/2017
LexicalTag NON
ThesaurusID NLM (2019); Granulin B
Term UI T000938319
Date12/27/2017
LexicalTag NON
ThesaurusID NLM (2019)

Granulin 1 Narrower

Granulin 2 Narrower

Paragranulin Narrower

Granulin 6 Narrower

Granulin 5 Narrower

Granulin 4 Narrower

Concept UI: M0181722
Registry Numbers: 0
Scope Note: Granulin from the fourth granulin repeat of the proteolytically processed mammalian progranulin protein. It is also called granulin A or epithelin 1.
Terms: Granulin 4 Preferred Term
Term UI T000938400
Date12/29/2017
LexicalTag NON
ThesaurusID NLM (2019); Epithelin 1
Term UI T000938396
Date12/29/2017
LexicalTag NON
ThesaurusID NLM (2019); Granulin A
Term UI T000938397
Date12/29/2017
LexicalTag NON
ThesaurusID NLM (2019); Epithelin-1
Term UI T000938398
Date12/29/2017
LexicalTag NON
ThesaurusID NLM (2019); Granulin Peptide (281-336)
Term UI T000938399
Date12/29/2017
LexicalTag NON
ThesaurusID NLM (2019)

Granulin 7 Narrower

Granulins MeSH Descriptor Data 2024