MeSH Browser

MeSH Heading: Bestrophins
Tree Number(s): D12.776.157.530.400.175.063; D12.776.306.228; D12.776.543.550.450.175.063; D12.776.543.585.400.175.063
Unique ID: D000075002
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000075002
Scope Note: A protein family characterized by a highly conserved N-terminus and four to six transmembrane helices; they function as bicarbonate permeable, calcium-activated chloride channels. Bestrophin-1 (BEST-1) and bestrophin-2 are highly expressed in human RETINAL PIGMENT EPITHELIUM cells and mutations in the BEST-1 gene are associated with VITELLIFORM MACULAR DYSTROPHY, TYPE 2.
Entry Term(s): BEST-1 Protein; BEST-2 Protein; Bestrophin; Bestrophin Family; Bestrophin Proteins; Bestrophin-1; Bestrophin-2
Previous Indexing: Chloride Channels (1999-2017); Eye Proteins (1999-2017)
Public MeSH Note: 2018
History Note: 2018
Date Established: 2018/01/01
Date of Entry: 2017/07/11
Revision Date: 2021/06/30

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M000628883
Scope Note: A protein family characterized by a highly conserved N-terminus and four to six transmembrane helices; they function as bicarbonate permeable, calcium-activated chloride channels. Bestrophin-1 (BEST-1) and bestrophin-2 are highly expressed in human RETINAL PIGMENT EPITHELIUM cells and mutations in the BEST-1 gene are associated with VITELLIFORM MACULAR DYSTROPHY, TYPE 2.
Terms: Bestrophins Preferred Term
Term UI T000919923
Date03/24/2017
LexicalTag NON
ThesaurusID NLM (2018); Bestrophin
Term UI T001089767
Date10/13/2020
LexicalTag NON
ThesaurusID NLM (2022); Bestrophin Family
Term UI T000919924
Date03/24/2017
LexicalTag NON
ThesaurusID NLM (2018); Bestrophin Proteins
Term UI T000919928
Date03/24/2017
LexicalTag NON
ThesaurusID NLM (2018)

Bestrophins MeSH Descriptor Data 2025