NLM Logo

Sirtuins MeSH Descriptor Data 2023


MeSH Heading
Sirtuins
Tree Number(s)
D08.811.277.087.520.200.650
D08.811.913.400.725.115.961
D12.776.476.900
Unique ID
D037761
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D037761
Scope Note
A homologous family of regulatory enzymes that are structurally related to the protein silent mating type information regulator 2 (Sir2) found in Saccharomyces cerevisiae. Sirtuins contain a central catalytic core region which binds NAD. Several of the sirtuins utilize NAD to deacetylate proteins such as HISTONES and are categorized as GROUP III HISTONE DEACETYLASES. Several other sirtuin members utilize NAD to transfer ADP-RIBOSE to proteins and are categorized as MONO ADP-RIBOSE TRANSFERASES, while a third group of sirtuins appears to have both deacetylase and ADP ribose transferase activities.
Entry Term(s)
SIRT
SIRTs
Silent Mating Type Information Regulator 2-like Proteins
Sir2-like Proteins
Sirtuin
Registry Number
EC 3.5.1.-
Previous Indexing
Histone Deacetylase (2000-2002)
See Also
Silent Information Regulator Proteins, Saccharomyces cerevisiae
Public MeSH Note
2003
History Note
2003
Date Established
2003/01/01
Date of Entry
2002/07/03
Revision Date
2020/05/27
Sirtuins Preferred
page delivered in 0.204s