MeSH Browser

MeSH Heading: Guanylate Cyclase
Tree Number(s): D08.811.520.650.600; D12.776.476.350
Unique ID: D006162
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D006162
Scope Note: An enzyme that catalyzes the conversion of GTP to 3',5'-cyclic GMP and pyrophosphate. It also acts on ITP and dGTP. (From Enzyme Nomenclature, 1992) EC 4.6.1.2.
Entry Term(s): Deoxyguanylate Cyclase; Guanyl Cyclase; Guanylyl Cyclase; Inosinate Cyclase
Registry Numbers: EC 4.6.1.2
Related Numbers: 9054-75-5
CAS Type 1 Name: GTP pyrophosphate-lyase (cyclizing)
Previous Indexing: Nucleotidyltransferases (1966-1972)
Public MeSH Note: 94; was GUANYL CYCLASE 1973-94
Online Note: use GUANYLATE CYCLASE to search GUANYL CYCLASE 1973-94
History Note: 94; was GUANYL CYCLASE 1973-94
Date Established: 1973/01/01
Date of Entry: 1999/01/01
Revision Date: 2021/05/21

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0009695
Registry Numbers: EC 4.6.1.2
Related Numbers: 9054-75-5
Scope Note: An enzyme that catalyzes the conversion of GTP to 3',5'-cyclic GMP and pyrophosphate. It also acts on ITP and dGTP. (From Enzyme Nomenclature, 1992) EC 4.6.1.2.
Terms: Guanylate Cyclase Preferred Term
Term UI T018696
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1973); Deoxyguanylate Cyclase
Term UI T018694
Date07/31/1980
LexicalTag NON
ThesaurusID UNK (19XX); Guanyl Cyclase
Term UI T018695
Date03/02/1994
LexicalTag NON
ThesaurusID NLM (1995); Inosinate Cyclase
Term UI T018697
Date08/01/1980
LexicalTag NON
ThesaurusID UNK (19XX); Guanylyl Cyclase
Term UI T627939
Date01/14/2005
LexicalTag NON
ThesaurusID NLM (2006)

Guanylate Cyclase MeSH Descriptor Data 2025