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RNA-Binding Protein EWS MeSH Descriptor Data 2023


MeSH Heading
RNA-Binding Protein EWS
Tree Number(s)
D12.644.360.650
D12.776.157.142.750
D12.776.157.725.813.750.900
D12.776.476.650
D12.776.624.664.700.913
D12.776.664.962.813.750.900
Unique ID
D034802
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D034802
Scope Note
A ubiquitous hnRNP protein that contains an RNA RECOGNITION MOTIF and C-terminal ranBP2-type zinc finger. It localizes to the CELL NUCLEUS and CYTOPLASM and is expressed as different isoforms in various tissues, interacting with CALMODULIN and TUMOR SUPPRESSOR PROTEIN P53 to negatively regulate cell growth. Translocations that result in the formation of fusion proteins containing parts of RNA-binding protein EWS are associated with EWING SARCOMA.
Entry Term(s)
EWS Protein
EWS Proto-Oncogene Protein
EWS RNA Binding Protein 1
EWSR1 Protein
Ewing Sarcoma Breakpoint Region 1 Protein
Ewing Sarcoma Breakpointregion 1 Protein
Registry Number
0
Previous Indexing
Ribonucleoproteins (1995-2002)
See Also
Zinc Fingers
Public MeSH Note
2003; EWS PROTEIN was indexed under RIBONUCLEOPROTEINS 1995-2002
History Note
2003; for EWS PROTEIN use HETEROGENEOUS-NUCLEAR RIBONUCLEOPROTEINS 1995-2002
Date Established
2003/01/01
Date of Entry
2002/07/03
Revision Date
2017/06/29
RNA-Binding Protein EWS Preferred
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