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A family of closely-related serine-threonine kinases that were originally identified as the cellular homologs of the retrovirus-derived V-RAF KINASES. They are MAP kinase kinase kinases that play important roles in SIGNAL TRANSDUCTION.
Entry Term(s)
MIL-RAF Proteins
Proto-Oncogene Proteins raf
mil-raf Protein Kinases
raf Kinase
raf MAP Kinase Kinase Kinases
raf Proto-Oncogene Proteins
raf Serine-Theonine Protein Kinases
Registry Numbers
EC 2.7.11.1
EC 2.7.11.1
Related Numbers
EC 2.7.11.1
Previous Indexing
Proto-Oncogene Proteins c-raf (1986-2004)
Public MeSH Note
2005; MIL-RAF PROTEIN KINASES & MIL-RAF PROTEINS was indexed under PROTEIN-SERINE-THREONINE KINASES 1993-97 & PROTO-ONCOGENE PROTEINS 1986-97
A family of closely-related serine-threonine kinases that were originally identified as the cellular homologs of the retrovirus-derived V-RAF KINASES. They are MAP kinase kinase kinases that play important roles in SIGNAL TRANSDUCTION.