MeSH Browser

MeSH Heading: raf Kinases
Tree Number(s): D08.811.913.696.620.682.700.559.842; D12.776.476.563.554.842; D12.776.624.664.700.204
Unique ID: D048490
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D048490
Scope Note: A family of closely-related serine-threonine kinases that were originally identified as the cellular homologs of the retrovirus-derived V-RAF KINASES. They are MAP kinase kinase kinases that play important roles in SIGNAL TRANSDUCTION.
Entry Term(s): MIL-RAF Proteins; Proto-Oncogene Proteins raf; mil-raf Protein Kinases; raf Kinase; raf MAP Kinase Kinase Kinases; raf Proto-Oncogene Proteins; raf Serine-Theonine Protein Kinases
Registry Numbers: EC 2.7.11.1; EC 2.7.11.1
Related Numbers: EC 2.7.11.1
Previous Indexing: Proto-Oncogene Proteins c-raf (1986-2004)
Public MeSH Note: 2005; MIL-RAF PROTEIN KINASES & MIL-RAF PROTEINS was indexed under PROTEIN-SERINE-THREONINE KINASES 1993-97 & PROTO-ONCOGENE PROTEINS 1986-97
History Note: 2005
Date Established: 2005/01/01
Date of Entry: 2004/07/07
Revision Date: 2021/05/21

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Transferases [D08.811.913]
    - Phosphotransferases [D08.811.913.696]
      - Phosphotransferases (Alcohol Group Acceptor) [D08.811.913.696.620]
        
        Protein Kinases [D08.811.913.696.620.682]
        
        Protein Serine-Threonine Kinases [D08.811.913.696.620.682.700]
        
        MAP Kinase Kinase Kinases [D08.811.913.696.620.682.700.559]
        
        MAP Kinase Kinase Kinase 1 [D08.811.913.696.620.682.700.559.100]
        
        MAP Kinase Kinase Kinase 2 [D08.811.913.696.620.682.700.559.200]
        
        MAP Kinase Kinase Kinase 3 [D08.811.913.696.620.682.700.559.300]
        
        MAP Kinase Kinase Kinase 4 [D08.811.913.696.620.682.700.559.400]
        
        MAP Kinase Kinase Kinase 5 [D08.811.913.696.620.682.700.559.500]
        
        Mitogen-Activated Protein Kinase Kinase Kinase 11 [D08.811.913.696.620.682.700.559.650]
        
        Proto-Oncogene Proteins c-mos [D08.811.913.696.620.682.700.559.800]
        
        raf Kinases [D08.811.913.696.620.682.700.559.842]
        
        Oncogene Proteins v-raf [D08.811.913.696.620.682.700.559.842.249]
        
        Proto-Oncogene Proteins B-raf [D08.811.913.696.620.682.700.559.842.374]
        
        Proto-Oncogene Proteins c-raf [D08.811.913.696.620.682.700.559.842.500]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Intracellular Signaling Peptides and Proteins [D12.776.476]
    - Protein Serine-Threonine Kinases [D12.776.476.563]
      - MAP Kinase Kinase Kinases [D12.776.476.563.554]
        
        MAP Kinase Kinase Kinase 1 [D12.776.476.563.554.100]
        
        MAP Kinase Kinase Kinase 2 [D12.776.476.563.554.200]
        
        MAP Kinase Kinase Kinase 3 [D12.776.476.563.554.300]
        
        MAP Kinase Kinase Kinase 4 [D12.776.476.563.554.400]
        
        MAP Kinase Kinase Kinase 5 [D12.776.476.563.554.500]
        
        Mitogen-Activated Protein Kinase Kinase Kinase 11 [D12.776.476.563.554.650]
        
        Proto-Oncogene Proteins c-mos [D12.776.476.563.554.800]
        
        raf Kinases [D12.776.476.563.554.842]
        
        Oncogene Proteins v-raf [D12.776.476.563.554.842.249]
        
        Proto-Oncogene Proteins A-raf [D12.776.476.563.554.842.374]
        
        Proto-Oncogene Proteins B-raf [D12.776.476.563.554.842.437]
        
        Proto-Oncogene Proteins c-raf [D12.776.476.563.554.842.500]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Neoplasm Proteins [D12.776.624]
    - Oncogene Proteins [D12.776.624.664]
      - Proto-Oncogene Proteins [D12.776.624.664.700]
        
        Axl Receptor Tyrosine Kinase [D12.776.624.664.700.013]
        
        Bcl-2-Like Protein 11 [D12.776.624.664.700.025]
        
        c-Mer Tyrosine Kinase [D12.776.624.664.700.037]
        
        Chemokine CXCL1 [D12.776.624.664.700.049]
        
        Cyclin D1 [D12.776.624.664.700.100]
        
        Fibroblast Growth Factor 4 [D12.776.624.664.700.110]
        
        Fibroblast Growth Factor 6 [D12.776.624.664.700.112]
        
        fms-Like Tyrosine Kinase 3 [D12.776.624.664.700.114]
        
        Janus Kinase 2 [D12.776.624.664.700.117]
        
        KRIT1 Protein [D12.776.624.664.700.119]
        
        Kruppel-Like Factor 6 [D12.776.624.664.700.120]
        
        Lipocalin-2 [D12.776.624.664.700.123]
        
        Lymphocyte Specific Protein Tyrosine Kinase p56(lck) [D12.776.624.664.700.128]
        
        MDS1 and EVI1 Complex Locus Protein [D12.776.624.664.700.129]
        
        MutS Homolog 2 Protein [D12.776.624.664.700.130]
        
        Myeloid-Lymphoid Leukemia Protein [D12.776.624.664.700.148]
        
        N-Myc Proto-Oncogene Protein [D12.776.624.664.700.158]
        
        Pre-B-Cell Leukemia Transcription Factor 1 [D12.776.624.664.700.163]
        
        B-Cell Lymphoma 3 Protein [D12.776.624.664.700.165]
        
        Proto-Oncogene Mas [D12.776.624.664.700.166]
        
        Proto-Oncogene Proteins c-abl [D12.776.624.664.700.167]
        
        Proto-Oncogene Proteins c-akt [D12.776.624.664.700.168]
        
        Proto-Oncogene Proteins c-bcl-2 [D12.776.624.664.700.169]
        
        Proto-Oncogene Proteins c-bcl-6 [D12.776.624.664.700.170]
        
        Proto-Oncogene Proteins c-bcr [D12.776.624.664.700.171]
        
        Proto-Oncogene Proteins c-cbl [D12.776.624.664.700.172]
        
        Proto-Oncogene Proteins c-crk [D12.776.624.664.700.174]
        
        Proto-Oncogene Proteins c-ets [D12.776.624.664.700.175]
        
        Proto-Oncogene Proteins c-fes [D12.776.624.664.700.177]
        
        Proto-Oncogene Proteins c-fos [D12.776.624.664.700.179]
        
        Proto-Oncogene Proteins c-fyn [D12.776.624.664.700.180]
        
        Proto-Oncogene Proteins c-hck [D12.776.624.664.700.181]
        
        Proto-Oncogene Proteins c-jun [D12.776.624.664.700.182]
        
        Proto-Oncogene Proteins c-kit [D12.776.624.664.700.183]
        
        Proto-Oncogene Proteins c-maf [D12.776.624.664.700.184]
        
        Proto-Oncogene Proteins c-mdm2 [D12.776.624.664.700.185]
        
        Proto-Oncogene Proteins c-met [D12.776.624.664.700.186]
        
        Proto-Oncogene Proteins c-mos [D12.776.624.664.700.187]
        
        Proto-Oncogene Proteins c-myb [D12.776.624.664.700.188]
        
        Proto-Oncogene Proteins c-myc [D12.776.624.664.700.189]
        
        Proto-Oncogene Proteins c-pim-1 [D12.776.624.664.700.191]
        
        Proto-Oncogene Proteins c-rel [D12.776.624.664.700.192]
        
        Proto-Oncogene Proteins c-ret [D12.776.624.664.700.194]
        
        Proto-Oncogene Proteins c-sis [D12.776.624.664.700.195]
        
        Proto-Oncogene Proteins c-vav [D12.776.624.664.700.198]
        
        Proto-Oncogene Proteins c-yes [D12.776.624.664.700.199]
        
        Proto-Oncogene Proteins p21(ras) [D12.776.624.664.700.200]
        
        Proto-Oncogene Proteins pp60(c-src) [D12.776.624.664.700.202]
        
        raf Kinases [D12.776.624.664.700.204]
        
        Proto-Oncogene Proteins B-raf [D12.776.624.664.700.204.200]
        
        Proto-Oncogene Proteins c-raf [D12.776.624.664.700.204.500]
        
        Receptor, ErbB-2 [D12.776.624.664.700.642]
        
        Receptor, ErbB-3 [D12.776.624.664.700.790]
        
        Receptor, ErbB-4 [D12.776.624.664.700.791]
        
        Receptor, Fibroblast Growth Factor, Type 3 [D12.776.624.664.700.792]
        
        Receptor, Macrophage Colony-Stimulating Factor [D12.776.624.664.700.800]
        
        Receptor, Notch4 [D12.776.624.664.700.815]
        
        Receptors, Thyroid Hormone [D12.776.624.664.700.830]
        
        RNA-Binding Protein EWS [D12.776.624.664.700.913]
        
        RNA-Binding Protein FUS [D12.776.624.664.700.915]
        
        RUNX1 Translocation Partner 1 Protein [D12.776.624.664.700.936]
        
        Stathmin [D12.776.624.664.700.957]
        
        T-Cell Acute Lymphocytic Leukemia Protein 1 [D12.776.624.664.700.960]
        
        Wnt-5a Protein [D12.776.624.664.700.962]
        
        Wnt1 Protein [D12.776.624.664.700.967]
        
        Wnt2 Protein [D12.776.624.664.700.978]
        
        Zinc Finger Protein GLI1 [D12.776.624.664.700.989]

raf Kinases Preferred

Concept UI: M0461520
Registry Numbers: EC 2.7.11.1
Related Numbers: EC 2.7.11.1
Scope Note: A family of closely-related serine-threonine kinases that were originally identified as the cellular homologs of the retrovirus-derived V-RAF KINASES. They are MAP kinase kinase kinases that play important roles in SIGNAL TRANSDUCTION.
Terms: raf Kinases Preferred Term
Term UI T574618
Date02/27/2004
LexicalTag ACX
ThesaurusID NLM (2005); Proto-Oncogene Proteins raf
Term UI T059321
Date05/21/1997
LexicalTag NON
ThesaurusID NLM (1998); raf Proto-Oncogene Proteins
Term UI T059322
Date05/21/1997
LexicalTag ACX
ThesaurusID NLM (1998); raf Serine-Theonine Protein Kinases
Term UI T574619
Date02/27/2004
LexicalTag ACX
ThesaurusID NLM (2005); raf MAP Kinase Kinase Kinases
Term UI T574620
Date02/27/2004
LexicalTag ACX
ThesaurusID NLM (2005); raf Kinase
Term UI T001083376
Date06/23/2020
LexicalTag NON
ThesaurusID NLM (2021)

mil-raf Protein Kinases Narrower

raf Kinases MeSH Descriptor Data 2025