Mitogen-Activated Protein Kinase Kinase Kinase 11 MeSH Descriptor Data 2025

MeSH Heading: Mitogen-Activated Protein Kinase Kinase Kinase 11
Tree Number(s): D08.811.913.696.620.682.700.559.650; D12.776.476.563.554.650
Unique ID: D000097767
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000097767
Scope Note: A MAP kinase kinase kinase that activates the SAPK/JNK and p38/ERK SIGNAL TRANSDUCTION pathways. It has multiple interaction domains, including a Cdc42 binding motif.
Entry Term(s): Mixed Lineage Kinase 3; Mixed Lineage Kinase-3
Public MeSH Note: 2024: MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 11 was indexed under MAP KINASE KINASE KINASES 2000-2023, and under PROTEIN-SERINE-THREONINE KINASES 1997-1999
History Note: 2024 (1997)
Date Established: 2024/01/01
Date of Entry: 2023/07/26
Revision Date: 2023/06/14

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Transferases [D08.811.913]
    - Phosphotransferases [D08.811.913.696]
      - Phosphotransferases (Alcohol Group Acceptor) [D08.811.913.696.620]
        
        Protein Kinases [D08.811.913.696.620.682]
        
        Protein Serine-Threonine Kinases [D08.811.913.696.620.682.700]
        
        MAP Kinase Kinase Kinases [D08.811.913.696.620.682.700.559]
        
        MAP Kinase Kinase Kinase 1 [D08.811.913.696.620.682.700.559.100]
        
        MAP Kinase Kinase Kinase 2 [D08.811.913.696.620.682.700.559.200]
        
        MAP Kinase Kinase Kinase 3 [D08.811.913.696.620.682.700.559.300]
        
        MAP Kinase Kinase Kinase 4 [D08.811.913.696.620.682.700.559.400]
        
        MAP Kinase Kinase Kinase 5 [D08.811.913.696.620.682.700.559.500]
        
        Mitogen-Activated Protein Kinase Kinase Kinase 11 [D08.811.913.696.620.682.700.559.650]
        
        Proto-Oncogene Proteins c-mos [D08.811.913.696.620.682.700.559.800]
        
        raf Kinases [D08.811.913.696.620.682.700.559.842]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Intracellular Signaling Peptides and Proteins [D12.776.476]
    - Protein Serine-Threonine Kinases [D12.776.476.563]
      - MAP Kinase Kinase Kinases [D12.776.476.563.554]
        
        MAP Kinase Kinase Kinase 1 [D12.776.476.563.554.100]
        
        MAP Kinase Kinase Kinase 2 [D12.776.476.563.554.200]
        
        MAP Kinase Kinase Kinase 3 [D12.776.476.563.554.300]
        
        MAP Kinase Kinase Kinase 4 [D12.776.476.563.554.400]
        
        MAP Kinase Kinase Kinase 5 [D12.776.476.563.554.500]
        
        Mitogen-Activated Protein Kinase Kinase Kinase 11 [D12.776.476.563.554.650]
        
        Proto-Oncogene Proteins c-mos [D12.776.476.563.554.800]
        
        raf Kinases [D12.776.476.563.554.842]

Mitogen-Activated Protein Kinase Kinase Kinase 11 Preferred

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