MeSH Browser

MeSH Heading: Receptor, Macrophage Colony-Stimulating Factor
Tree Number(s): D08.811.913.696.620.682.725.400.500; D12.776.476.568.400.500; D12.776.543.750.630.492; D12.776.543.750.705.852.150.150; D12.776.543.750.750.400.200.200; D12.776.624.664.700.800
Unique ID: D016186
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D016186
Scope Note: A receptor for MACROPHAGE COLONY-STIMULATING FACTOR encoded by the c-fms proto-oncogene (GENES, FMS). It contains an intrinsic protein-tyrosine kinase activity. When activated the receptor undergoes autophosphorylation, phosphorylation of down-stream signaling molecules and rapid down-regulation.
Entry Version: RECEPT MCSF
Entry Term(s): Antigens, CD115; CD115 Antigen; CD115 Antigens; CSF-1 Receptor; M-CSF Receptor; M-CSF Receptors; Macrophage Colony-Stimulating Factor Receptor; Macrophage Colony-Stimulating Factor Receptors; Proto-Oncogene Protein fms; Receptor, CSF-1; Receptors, CSF-1; Receptors, M-CSF; Receptors, Macrophage Colony-Stimulating Factor; c-fms Protein; fms Proto-Oncogene Protein
Previous Indexing: Proto-Oncogene Proteins (1986-1990); Receptors, Endogenous Substances (1973-1990)
See Also: Genes, fms
Public MeSH Note: 2000; was RECEPTORS, MACROPHAGE COLONY-STIMULATING FACTOR 1993-1999; was RECEPTOR, MACROPHAGE COLONY-STIMULATING FACTOR 1991-1992
History Note: 2000(1991)
Date Established: 1991/01/01
Date of Entry: 1990/06/19
Revision Date: 2021/05/21

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Transferases [D08.811.913]
    - Phosphotransferases [D08.811.913.696]
      - Phosphotransferases (Alcohol Group Acceptor) [D08.811.913.696.620]
        
        Protein Kinases [D08.811.913.696.620.682]
        
        Protein-Tyrosine Kinases [D08.811.913.696.620.682.725]
        
        Receptor Protein-Tyrosine Kinases [D08.811.913.696.620.682.725.400]
        
        Anaplastic Lymphoma Kinase [D08.811.913.696.620.682.725.400.002]
        
        c-Mer Tyrosine Kinase [D08.811.913.696.620.682.725.400.003]
        
        Discoidin Domain Receptors [D08.811.913.696.620.682.725.400.005]
        
        ErbB Receptors [D08.811.913.696.620.682.725.400.009]
        
        fms-Like Tyrosine Kinase 3 [D08.811.913.696.620.682.725.400.020]
        
        Proto-Oncogene Proteins c-kit [D08.811.913.696.620.682.725.400.050]
        
        Proto-Oncogene Proteins c-met [D08.811.913.696.620.682.725.400.075]
        
        Proto-Oncogene Proteins c-ret [D08.811.913.696.620.682.725.400.087]
        
        Receptor Tyrosine Kinase-like Orphan Receptors [D08.811.913.696.620.682.725.400.093]
        
        Receptor, Fibroblast Growth Factor, Type 1 [D08.811.913.696.620.682.725.400.177]
        
        Receptor, Fibroblast Growth Factor, Type 2 [D08.811.913.696.620.682.725.400.178]
        
        Receptor, Fibroblast Growth Factor, Type 3 [D08.811.913.696.620.682.725.400.179]
        
        Receptor, Fibroblast Growth Factor, Type 4 [D08.811.913.696.620.682.725.400.180]
        
        Receptor, IGF Type 1 [D08.811.913.696.620.682.725.400.185]
        
        Receptor, Insulin [D08.811.913.696.620.682.725.400.200]
        
        Receptor, Macrophage Colony-Stimulating Factor [D08.811.913.696.620.682.725.400.500]
        
        Receptor, trkA [D08.811.913.696.620.682.725.400.660]
        
        Receptor, trkB [D08.811.913.696.620.682.725.400.700]
        
        Receptor, trkC [D08.811.913.696.620.682.725.400.800]
        
        Receptors, Eph Family [D08.811.913.696.620.682.725.400.850]
        
        Receptors, Platelet-Derived Growth Factor [D08.811.913.696.620.682.725.400.900]
        
        Receptors, TIE [D08.811.913.696.620.682.725.400.925]
        
        Receptors, Vascular Endothelial Growth Factor [D08.811.913.696.620.682.725.400.950]
        
        Axl Receptor Tyrosine Kinase [D08.811.913.696.620.682.725.400.975]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Intracellular Signaling Peptides and Proteins [D12.776.476]
    - Protein-Tyrosine Kinases [D12.776.476.568]
      - Receptor Protein-Tyrosine Kinases [D12.776.476.568.400]
        
        Anaplastic Lymphoma Kinase [D12.776.476.568.400.002]
        
        c-Mer Tyrosine Kinase [D12.776.476.568.400.003]
        
        Discoidin Domain Receptors [D12.776.476.568.400.005]
        
        ErbB Receptors [D12.776.476.568.400.009]
        
        fms-Like Tyrosine Kinase 3 [D12.776.476.568.400.020]
        
        Proto-Oncogene Proteins c-kit [D12.776.476.568.400.050]
        
        Proto-Oncogene Proteins c-met [D12.776.476.568.400.075]
        
        Proto-Oncogene Proteins c-ret [D12.776.476.568.400.087]
        
        Receptor Tyrosine Kinase-like Orphan Receptors [D12.776.476.568.400.093]
        
        Receptor, Fibroblast Growth Factor, Type 1 [D12.776.476.568.400.177]
        
        Receptor, Fibroblast Growth Factor, Type 2 [D12.776.476.568.400.178]
        
        Receptor, Fibroblast Growth Factor, Type 3 [D12.776.476.568.400.179]
        
        Receptor, Fibroblast Growth Factor, Type 4 [D12.776.476.568.400.180]
        
        Receptor, IGF Type 1 [D12.776.476.568.400.185]
        
        Receptor, Insulin [D12.776.476.568.400.200]
        
        Receptor, Macrophage Colony-Stimulating Factor [D12.776.476.568.400.500]
        
        Receptor, trkA [D12.776.476.568.400.660]
        
        Receptor, trkB [D12.776.476.568.400.700]
        
        Receptor, trkC [D12.776.476.568.400.800]
        
        Receptors, Eph Family [D12.776.476.568.400.850]
        
        Receptors, Platelet-Derived Growth Factor [D12.776.476.568.400.900]
        
        Receptors, TIE [D12.776.476.568.400.925]
        
        Receptors, Vascular Endothelial Growth Factor [D12.776.476.568.400.950]
        
        Axl Receptor Tyrosine Kinase [D12.776.476.568.400.975]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Membrane Proteins [D12.776.543]
    - Receptors, Cell Surface [D12.776.543.750]
      - Receptor Protein-Tyrosine Kinases [D12.776.543.750.630]
        
        Anaplastic Lymphoma Kinase [D12.776.543.750.630.002]
        
        c-Mer Tyrosine Kinase [D12.776.543.750.630.003]
        
        Discoidin Domain Receptors [D12.776.543.750.630.005]
        
        ErbB Receptors [D12.776.543.750.630.009]
        
        fms-Like Tyrosine Kinase 3 [D12.776.543.750.630.020]
        
        Proto-Oncogene Proteins c-kit [D12.776.543.750.630.124]
        
        Proto-Oncogene Proteins c-met [D12.776.543.750.630.186]
        
        Proto-Oncogene Proteins c-ret [D12.776.543.750.630.217]
        
        Receptor Tyrosine Kinase-like Orphan Receptors [D12.776.543.750.630.233]
        
        Receptor, Fibroblast Growth Factor, Type 1 [D12.776.543.750.630.440]
        
        Receptor, Fibroblast Growth Factor, Type 2 [D12.776.543.750.630.441]
        
        Receptor, Fibroblast Growth Factor, Type 3 [D12.776.543.750.630.442]
        
        Receptor, Fibroblast Growth Factor, Type 4 [D12.776.543.750.630.443]
        
        Receptor, IGF Type 1 [D12.776.543.750.630.468]
        
        Receptor, Insulin [D12.776.543.750.630.484]
        
        Receptor, Macrophage Colony-Stimulating Factor [D12.776.543.750.630.492]
        
        Receptor, trkA [D12.776.543.750.630.496]
        
        Receptor, trkB [D12.776.543.750.630.498]
        
        Receptor, trkC [D12.776.543.750.630.499]
        
        Receptors, Eph Family [D12.776.543.750.630.500]
        
        Receptors, Platelet-Derived Growth Factor [D12.776.543.750.630.625]
        
        Receptors, TIE [D12.776.543.750.630.687]
        
        Receptors, Vascular Endothelial Growth Factor [D12.776.543.750.630.750]
        
        Axl Receptor Tyrosine Kinase [D12.776.543.750.630.875]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Membrane Proteins [D12.776.543]
    - Receptors, Cell Surface [D12.776.543.750]
      - Receptors, Immunologic [D12.776.543.750.705]
        
        Receptors, Cytokine [D12.776.543.750.705.852]
        
        Receptors, Colony-Stimulating Factor [D12.776.543.750.705.852.150]
        
        Proto-Oncogene Proteins c-kit [D12.776.543.750.705.852.150.100]
        
        Receptor, Macrophage Colony-Stimulating Factor [D12.776.543.750.705.852.150.150]
        
        Receptors, Erythropoietin [D12.776.543.750.705.852.150.200]
        
        Receptors, Granulocyte Colony-Stimulating Factor [D12.776.543.750.705.852.150.280]
        
        Receptors, Granulocyte-Macrophage Colony-Stimulating Factor [D12.776.543.750.705.852.150.310]
        
        Receptors, Interleukin-3 [D12.776.543.750.705.852.150.360]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Membrane Proteins [D12.776.543]
    - Receptors, Cell Surface [D12.776.543.750]
      - Receptors, Peptide [D12.776.543.750.750]
        
        Receptors, Growth Factor [D12.776.543.750.750.400]
        
        Receptors, Colony-Stimulating Factor [D12.776.543.750.750.400.200]
        
        Proto-Oncogene Proteins c-kit [D12.776.543.750.750.400.200.170]
        
        Receptor, Macrophage Colony-Stimulating Factor [D12.776.543.750.750.400.200.200]
        
        Receptors, Erythropoietin [D12.776.543.750.750.400.200.340]
        
        Receptors, Granulocyte Colony-Stimulating Factor [D12.776.543.750.750.400.200.400]
        
        Receptors, Granulocyte-Macrophage Colony-Stimulating Factor [D12.776.543.750.750.400.200.420]
        
        Receptors, Interleukin-3 [D12.776.543.750.750.400.200.480]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Neoplasm Proteins [D12.776.624]
    - Oncogene Proteins [D12.776.624.664]
      - Proto-Oncogene Proteins [D12.776.624.664.700]
        
        Axl Receptor Tyrosine Kinase [D12.776.624.664.700.013]
        
        Bcl-2-Like Protein 11 [D12.776.624.664.700.025]
        
        c-Mer Tyrosine Kinase [D12.776.624.664.700.037]
        
        Chemokine CXCL1 [D12.776.624.664.700.049]
        
        Cyclin D1 [D12.776.624.664.700.100]
        
        Fibroblast Growth Factor 4 [D12.776.624.664.700.110]
        
        Fibroblast Growth Factor 6 [D12.776.624.664.700.112]
        
        fms-Like Tyrosine Kinase 3 [D12.776.624.664.700.114]
        
        Janus Kinase 2 [D12.776.624.664.700.117]
        
        KRIT1 Protein [D12.776.624.664.700.119]
        
        Kruppel-Like Factor 6 [D12.776.624.664.700.120]
        
        Lipocalin-2 [D12.776.624.664.700.123]
        
        Lymphocyte Specific Protein Tyrosine Kinase p56(lck) [D12.776.624.664.700.128]
        
        MDS1 and EVI1 Complex Locus Protein [D12.776.624.664.700.129]
        
        MutS Homolog 2 Protein [D12.776.624.664.700.130]
        
        Myeloid-Lymphoid Leukemia Protein [D12.776.624.664.700.148]
        
        N-Myc Proto-Oncogene Protein [D12.776.624.664.700.158]
        
        Pre-B-Cell Leukemia Transcription Factor 1 [D12.776.624.664.700.163]
        
        B-Cell Lymphoma 3 Protein [D12.776.624.664.700.165]
        
        Proto-Oncogene Mas [D12.776.624.664.700.166]
        
        Proto-Oncogene Proteins c-abl [D12.776.624.664.700.167]
        
        Proto-Oncogene Proteins c-akt [D12.776.624.664.700.168]
        
        Proto-Oncogene Proteins c-bcl-2 [D12.776.624.664.700.169]
        
        Proto-Oncogene Proteins c-bcl-6 [D12.776.624.664.700.170]
        
        Proto-Oncogene Proteins c-bcr [D12.776.624.664.700.171]
        
        Proto-Oncogene Proteins c-cbl [D12.776.624.664.700.172]
        
        Proto-Oncogene Proteins c-crk [D12.776.624.664.700.174]
        
        Proto-Oncogene Proteins c-ets [D12.776.624.664.700.175]
        
        Proto-Oncogene Proteins c-fes [D12.776.624.664.700.177]
        
        Proto-Oncogene Proteins c-fos [D12.776.624.664.700.179]
        
        Proto-Oncogene Proteins c-fyn [D12.776.624.664.700.180]
        
        Proto-Oncogene Proteins c-hck [D12.776.624.664.700.181]
        
        Proto-Oncogene Proteins c-jun [D12.776.624.664.700.182]
        
        Proto-Oncogene Proteins c-kit [D12.776.624.664.700.183]
        
        Proto-Oncogene Proteins c-maf [D12.776.624.664.700.184]
        
        Proto-Oncogene Proteins c-mdm2 [D12.776.624.664.700.185]
        
        Proto-Oncogene Proteins c-met [D12.776.624.664.700.186]
        
        Proto-Oncogene Proteins c-mos [D12.776.624.664.700.187]
        
        Proto-Oncogene Proteins c-myb [D12.776.624.664.700.188]
        
        Proto-Oncogene Proteins c-myc [D12.776.624.664.700.189]
        
        Proto-Oncogene Proteins c-pim-1 [D12.776.624.664.700.191]
        
        Proto-Oncogene Proteins c-rel [D12.776.624.664.700.192]
        
        Proto-Oncogene Proteins c-ret [D12.776.624.664.700.194]
        
        Proto-Oncogene Proteins c-sis [D12.776.624.664.700.195]
        
        Proto-Oncogene Proteins c-vav [D12.776.624.664.700.198]
        
        Proto-Oncogene Proteins c-yes [D12.776.624.664.700.199]
        
        Proto-Oncogene Proteins p21(ras) [D12.776.624.664.700.200]
        
        Proto-Oncogene Proteins pp60(c-src) [D12.776.624.664.700.202]
        
        raf Kinases [D12.776.624.664.700.204]
        
        Receptor, ErbB-2 [D12.776.624.664.700.642]
        
        Receptor, ErbB-3 [D12.776.624.664.700.790]
        
        Receptor, ErbB-4 [D12.776.624.664.700.791]
        
        Receptor, Fibroblast Growth Factor, Type 3 [D12.776.624.664.700.792]
        
        Receptor, Macrophage Colony-Stimulating Factor [D12.776.624.664.700.800]
        
        Receptor, Notch4 [D12.776.624.664.700.815]
        
        Receptors, Thyroid Hormone [D12.776.624.664.700.830]
        
        RNA-Binding Protein EWS [D12.776.624.664.700.913]
        
        RNA-Binding Protein FUS [D12.776.624.664.700.915]
        
        RUNX1 Translocation Partner 1 Protein [D12.776.624.664.700.936]
        
        Stathmin [D12.776.624.664.700.957]
        
        T-Cell Acute Lymphocytic Leukemia Protein 1 [D12.776.624.664.700.960]
        
        Wnt-5a Protein [D12.776.624.664.700.962]
        
        Wnt1 Protein [D12.776.624.664.700.967]
        
        Wnt2 Protein [D12.776.624.664.700.978]
        
        Zinc Finger Protein GLI1 [D12.776.624.664.700.989]

Receptor, Macrophage Colony-Stimulating Factor Preferred

Concept UI: M0024703
Scope Note: A receptor for MACROPHAGE COLONY-STIMULATING FACTOR encoded by the c-fms proto-oncogene (GENES, FMS). It contains an intrinsic protein-tyrosine kinase activity. When activated the receptor undergoes autophosphorylation, phosphorylation of down-stream signaling molecules and rapid down-regulation.
Terms: Receptor, Macrophage Colony-Stimulating Factor Preferred Term
Term UI T048102
Date07/17/1992
LexicalTag NON
ThesaurusID NLM (1993); M-CSF Receptor
Term UI T000998887
Date11/21/2019
LexicalTag NON
ThesaurusID NLM (2021); c-fms Protein
Term UI T048094
Date04/11/1990
LexicalTag NON
ThesaurusID NLM (1991); Receptor, CSF-1
Term UI T048095
Date03/05/1993
LexicalTag NON
ThesaurusID NLM (1994); Receptors, CSF-1
Term UI T048096
Date04/29/1992
LexicalTag NON
ThesaurusID NLM (1993); fms Proto-Oncogene Protein
Term UI T048098
Date04/11/1990
LexicalTag NON
ThesaurusID NLM (1991); Proto-Oncogene Protein fms
Term UI T048099
Date02/17/1990
LexicalTag NON
ThesaurusID NLM (1991); M-CSF Receptors
Term UI T048100
Date02/17/1990
LexicalTag NON
ThesaurusID NLM (1991); Receptors, M-CSF
Term UI T048101
Date04/29/1992
LexicalTag NON
ThesaurusID NLM (1993); Receptors, Macrophage Colony-Stimulating Factor
Term UI T048103
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1991); CD115 Antigen
Term UI T048104
Date03/09/1995
LexicalTag NON
ThesaurusID NLM (1996); Antigens, CD115
Term UI T048105
Date07/26/1994
LexicalTag NON
ThesaurusID NLM (1996); CD115 Antigens
Term UI T048106
Date01/26/1995
LexicalTag NON
ThesaurusID NLM (1996); CSF-1 Receptor
Term UI T363202
Date11/08/1999
LexicalTag NON
ThesaurusID NLM (2000); Macrophage Colony-Stimulating Factor Receptor
Term UI T000998885
Date11/21/2019
LexicalTag NON
ThesaurusID NLM (2021); Macrophage Colony-Stimulating Factor Receptors
Term UI T618289
Date11/17/2004
LexicalTag NON
ThesaurusID NLM (2006)

Receptor, Macrophage Colony-Stimulating Factor MeSH Descriptor Data 2025