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Receptor Tyrosine Kinase-like Orphan Receptors MeSH Descriptor Data 2022


MeSH Heading
Receptor Tyrosine Kinase-like Orphan Receptors
Tree Number(s)
D08.811.913.696.620.682.725.400.093
D12.776.476.568.400.093
D12.776.543.750.630.233
Unique ID
D057050
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D057050
Annotation
do not confuse with ORPHAN NUCLEAR RECEPTORS
Scope Note
A family of cell surface receptors that were originally identified by their structural homology to neurotropic TYROSINE KINASES and referred to as orphan receptors because the associated ligand and signaling pathways were unknown. Evidence for the functionality of these proteins has been established by experiments showing that disruption of the orphan receptor genes results in developmental defects.
Entry Term(s)
NTRKR Receptors
Neurotrophic Tyrosine Kinase, Receptor-related Proteins
ROR Tyrosine Kinase Receptors
ROR1 Tyrosine Kinase
ROR2 Tyrosine Kinase
Receptor Tyrosine Kinase-like Orphan Receptor
Receptor Tyrosine Kinase-like Orphan Receptor 1
Receptor Tyrosine Kinase-like Orphan Receptor 2
Registry Number
EC 2.7.10.1
Related Numbers
EC 2.7.10.1
Previous Indexing
Protein-Tyrosine Kinase (1983-1993)
Receptor Protein-Tyrosine Kinases (1994-2009)
Public MeSH Note
2010
History Note
2010
Date Established
2010/01/01
Date of Entry
2009/07/06
Revision Date
2021/06/30
Receptor Tyrosine Kinase-like Orphan Receptors Preferred
Receptor Tyrosine Kinase-like Orphan Receptor 2 Narrower
Receptor Tyrosine Kinase-like Orphan Receptor 1 Narrower
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