MeSH Browser

MeSH Heading: Discoidin Domain Receptors
Tree Number(s): D08.811.913.696.620.682.725.400.005; D12.776.476.568.400.005; D12.776.543.750.630.005; D12.776.543.750.685.050; D12.776.543.750.705.880.300
Unique ID: D000070818
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000070818
Scope Note: Receptor tyrosine kinases that bind COLLAGENS. They are characterized by the presence of extracellular DISCOIDIN DOMAINS that activate SIGNAL TRANSDUCTION PATHWAYS in response to collagen binding. They may also be cleaved by MATRIX METALLOPROTEINASES to mediate cell interactions with the EXTRACELLULAR MATRIX.
Entry Term(s): DDR Proteins; Discoidin Domain Receptor
Registry Numbers: EC 2.7.10.1
Public MeSH Note: 2017; DISCOIDIN DOMAIN RECEPTORS was indexed under RECEPTORS, MITOGEN and RECEPTOR PROTEIN-TYROSINE KINASES 1999-2016
History Note: 2017 (1999)
Date Established: 2017/01/01
Date of Entry: 2016/07/08
Revision Date: 2021/05/21

Allowable Qualifiers: administration & dosage (AD)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

physiology (PH)

radiation effects (RE)

therapeutic use (TU)

ultrastructure (UL)

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Transferases [D08.811.913]
    - Phosphotransferases [D08.811.913.696]
      - Phosphotransferases (Alcohol Group Acceptor) [D08.811.913.696.620]
        
        Protein Kinases [D08.811.913.696.620.682]
        
        Protein-Tyrosine Kinases [D08.811.913.696.620.682.725]
        
        Receptor Protein-Tyrosine Kinases [D08.811.913.696.620.682.725.400]
        
        Anaplastic Lymphoma Kinase [D08.811.913.696.620.682.725.400.002]
        
        c-Mer Tyrosine Kinase [D08.811.913.696.620.682.725.400.003]
        
        Discoidin Domain Receptors [D08.811.913.696.620.682.725.400.005]
        
        Discoidin Domain Receptor 1 [D08.811.913.696.620.682.725.400.005.500]
        
        Discoidin Domain Receptor 2 [D08.811.913.696.620.682.725.400.005.750]
        
        ErbB Receptors [D08.811.913.696.620.682.725.400.009]
        
        fms-Like Tyrosine Kinase 3 [D08.811.913.696.620.682.725.400.020]
        
        Proto-Oncogene Proteins c-kit [D08.811.913.696.620.682.725.400.050]
        
        Proto-Oncogene Proteins c-met [D08.811.913.696.620.682.725.400.075]
        
        Proto-Oncogene Proteins c-ret [D08.811.913.696.620.682.725.400.087]
        
        Receptor Tyrosine Kinase-like Orphan Receptors [D08.811.913.696.620.682.725.400.093]
        
        Receptor, Fibroblast Growth Factor, Type 1 [D08.811.913.696.620.682.725.400.177]
        
        Receptor, Fibroblast Growth Factor, Type 2 [D08.811.913.696.620.682.725.400.178]
        
        Receptor, Fibroblast Growth Factor, Type 3 [D08.811.913.696.620.682.725.400.179]
        
        Receptor, Fibroblast Growth Factor, Type 4 [D08.811.913.696.620.682.725.400.180]
        
        Receptor, IGF Type 1 [D08.811.913.696.620.682.725.400.185]
        
        Receptor, Insulin [D08.811.913.696.620.682.725.400.200]
        
        Receptor, Macrophage Colony-Stimulating Factor [D08.811.913.696.620.682.725.400.500]
        
        Receptor, trkA [D08.811.913.696.620.682.725.400.660]
        
        Receptor, trkB [D08.811.913.696.620.682.725.400.700]
        
        Receptor, trkC [D08.811.913.696.620.682.725.400.800]
        
        Receptors, Eph Family [D08.811.913.696.620.682.725.400.850]
        
        Receptors, Platelet-Derived Growth Factor [D08.811.913.696.620.682.725.400.900]
        
        Receptors, TIE [D08.811.913.696.620.682.725.400.925]
        
        Receptors, Vascular Endothelial Growth Factor [D08.811.913.696.620.682.725.400.950]
        
        Axl Receptor Tyrosine Kinase [D08.811.913.696.620.682.725.400.975]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Intracellular Signaling Peptides and Proteins [D12.776.476]
    - Protein-Tyrosine Kinases [D12.776.476.568]
      - Receptor Protein-Tyrosine Kinases [D12.776.476.568.400]
        
        Anaplastic Lymphoma Kinase [D12.776.476.568.400.002]
        
        c-Mer Tyrosine Kinase [D12.776.476.568.400.003]
        
        Discoidin Domain Receptors [D12.776.476.568.400.005]
        
        Discoidin Domain Receptor 1 [D12.776.476.568.400.005.500]
        
        Discoidin Domain Receptor 2 [D12.776.476.568.400.005.750]
        
        ErbB Receptors [D12.776.476.568.400.009]
        
        fms-Like Tyrosine Kinase 3 [D12.776.476.568.400.020]
        
        Proto-Oncogene Proteins c-kit [D12.776.476.568.400.050]
        
        Proto-Oncogene Proteins c-met [D12.776.476.568.400.075]
        
        Proto-Oncogene Proteins c-ret [D12.776.476.568.400.087]
        
        Receptor Tyrosine Kinase-like Orphan Receptors [D12.776.476.568.400.093]
        
        Receptor, Fibroblast Growth Factor, Type 1 [D12.776.476.568.400.177]
        
        Receptor, Fibroblast Growth Factor, Type 2 [D12.776.476.568.400.178]
        
        Receptor, Fibroblast Growth Factor, Type 3 [D12.776.476.568.400.179]
        
        Receptor, Fibroblast Growth Factor, Type 4 [D12.776.476.568.400.180]
        
        Receptor, IGF Type 1 [D12.776.476.568.400.185]
        
        Receptor, Insulin [D12.776.476.568.400.200]
        
        Receptor, Macrophage Colony-Stimulating Factor [D12.776.476.568.400.500]
        
        Receptor, trkA [D12.776.476.568.400.660]
        
        Receptor, trkB [D12.776.476.568.400.700]
        
        Receptor, trkC [D12.776.476.568.400.800]
        
        Receptors, Eph Family [D12.776.476.568.400.850]
        
        Receptors, Platelet-Derived Growth Factor [D12.776.476.568.400.900]
        
        Receptors, TIE [D12.776.476.568.400.925]
        
        Receptors, Vascular Endothelial Growth Factor [D12.776.476.568.400.950]
        
        Axl Receptor Tyrosine Kinase [D12.776.476.568.400.975]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Membrane Proteins [D12.776.543]
    - Receptors, Cell Surface [D12.776.543.750]
      - Receptor Protein-Tyrosine Kinases [D12.776.543.750.630]
        
        Anaplastic Lymphoma Kinase [D12.776.543.750.630.002]
        
        c-Mer Tyrosine Kinase [D12.776.543.750.630.003]
        
        Discoidin Domain Receptors [D12.776.543.750.630.005]
        
        Discoidin Domain Receptor 1 [D12.776.543.750.630.005.500]
        
        Discoidin Domain Receptor 2 [D12.776.543.750.630.005.750]
        
        ErbB Receptors [D12.776.543.750.630.009]
        
        fms-Like Tyrosine Kinase 3 [D12.776.543.750.630.020]
        
        Proto-Oncogene Proteins c-kit [D12.776.543.750.630.124]
        
        Proto-Oncogene Proteins c-met [D12.776.543.750.630.186]
        
        Proto-Oncogene Proteins c-ret [D12.776.543.750.630.217]
        
        Receptor Tyrosine Kinase-like Orphan Receptors [D12.776.543.750.630.233]
        
        Receptor, Fibroblast Growth Factor, Type 1 [D12.776.543.750.630.440]
        
        Receptor, Fibroblast Growth Factor, Type 2 [D12.776.543.750.630.441]
        
        Receptor, Fibroblast Growth Factor, Type 3 [D12.776.543.750.630.442]
        
        Receptor, Fibroblast Growth Factor, Type 4 [D12.776.543.750.630.443]
        
        Receptor, IGF Type 1 [D12.776.543.750.630.468]
        
        Receptor, Insulin [D12.776.543.750.630.484]
        
        Receptor, Macrophage Colony-Stimulating Factor [D12.776.543.750.630.492]
        
        Receptor, trkA [D12.776.543.750.630.496]
        
        Receptor, trkB [D12.776.543.750.630.498]
        
        Receptor, trkC [D12.776.543.750.630.499]
        
        Receptors, Eph Family [D12.776.543.750.630.500]
        
        Receptors, Platelet-Derived Growth Factor [D12.776.543.750.630.625]
        
        Receptors, TIE [D12.776.543.750.630.687]
        
        Receptors, Vascular Endothelial Growth Factor [D12.776.543.750.630.750]
        
        Axl Receptor Tyrosine Kinase [D12.776.543.750.630.875]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Membrane Proteins [D12.776.543]
    - Receptors, Cell Surface [D12.776.543.750]
      - Receptors, Collagen [D12.776.543.750.685]
        
        Discoidin Domain Receptors [D12.776.543.750.685.050]
        
        Discoidin Domain Receptor 1 [D12.776.543.750.685.050.500]
        
        Discoidin Domain Receptor 2 [D12.776.543.750.685.050.750]
        
        Integrin alpha1beta1 [D12.776.543.750.685.100]
        
        Integrin alpha2beta1 [D12.776.543.750.685.200]
        
        Integrin alpha3beta1 [D12.776.543.750.685.300]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Membrane Proteins [D12.776.543]
    - Receptors, Cell Surface [D12.776.543.750]
      - Receptors, Immunologic [D12.776.543.750.705]
        
        Receptors, Mitogen [D12.776.543.750.705.880]
        
        Discoidin Domain Receptors [D12.776.543.750.705.880.300]
        
        Discoidin Domain Receptor 1 [D12.776.543.750.705.880.300.500]
        
        Discoidin Domain Receptor 2 [D12.776.543.750.705.880.300.750]
        
        Receptors, Concanavalin A [D12.776.543.750.705.880.600]

Discoidin Domain Receptors Preferred

Concept UI: M0134195
Registry Numbers: EC 2.7.10.1
Scope Note: Receptor tyrosine kinases that bind COLLAGENS. They are characterized by the presence of extracellular DISCOIDIN DOMAINS that activate SIGNAL TRANSDUCTION PATHWAYS in response to collagen binding. They may also be cleaved by MATRIX METALLOPROTEINASES to mediate cell interactions with the EXTRACELLULAR MATRIX.
Terms: Discoidin Domain Receptors Preferred Term
Term UI T000891429
Date12/01/2015
LexicalTag NON
ThesaurusID NLM (2017); Discoidin Domain Receptor
Term UI T000891428
Date12/01/2015
LexicalTag NON
ThesaurusID NLM (1999); DDR Proteins
Term UI T000891432
Date12/01/2015
LexicalTag ABX
ThesaurusID NLM (2017)

Discoidin Domain Receptors MeSH Descriptor Data 2025