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Discoidin Domain MeSH Descriptor Data 2022


MeSH Heading
Discoidin Domain
Tree Number(s)
G02.111.570.820.709.275.750.219
Unique ID
D000070822
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D000070822
Scope Note
A protein domain originally identified in DISCOIDINS. It occurs in a variety of unrelated proteins in multicellular organisms, where it recognizes different ligands with distinct biological functions. Structurally, it consists of two antiparallel beta sheets that form a "jellyroll" configuration stabilized by two intramolecular disulfide bonds. Sequence differences within this module determine ligand specificity; in DISCOIDIN DOMAIN RECEPTORS, it binds to FIBRILLAR COLLAGENS and NON-FIBRILLAR COLLAGENS.
Entry Term(s)
Discoidin Domains
Previous Indexing
Lectins (1998-2016)
Protein Structure, Tertiary (1998-2016)
Public MeSH Note
2017
History Note
2017
Date Established
2017/01/01
Date of Entry
2016/07/08
Revision Date
2016/05/09
Discoidin Domain Preferred
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