MeSH Browser

MeSH Heading: Pleckstrin Homology Domains
Tree Number(s): G02.111.570.820.709.275.750.469
Unique ID: D000070539
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000070539
Scope Note: Protein domains of approximately 120 amino acids that form two perpendicular anti-parallel beta sheets connected by a loop of variable length and a C-terminal amphipathic helix. PH domains occur in many INTRACELLULAR SIGNALING PROTEINS and CYTOSKELETAL PROTEINS where they bind PHOSPHATIDYLINOSITOLS within the CELL MEMBRANE and INTRACELLULAR MEMBRANES, as well as proteins that include the Betagamma-subunits of HETEROTRIMERIC GTP-BINDING PROTEINS, and PROTEIN KINASE C. These interactions allow the targeting of proteins to different cellular compartments and SIGNAL TRANSDUCTION PATHWAYS.
Entry Term(s): PH Domain; PH Domains; Pleckstrin Homology Domain
Previous Indexing: Protein Structure, Tertiary (1994-2016)
Public MeSH Note: 2017
History Note: 2017
Date Established: 2017/01/01
Date of Entry: 2016/07/08
Revision Date: 2016/05/09

Allowable Qualifiers: drug effects (DE)

genetics (GE)

immunology (IM)

physiology (PH)

radiation effects (RE)

Pleckstrin Homology Domains MeSH Descriptor Data 2025