MeSH Browser

MeSH Heading: HMG-Box Domains
Tree Number(s): G02.111.570.820.709.275.750.235
Unique ID: D024742
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D024742
Annotation: HIGH MOBILITY GROUP PROTEINS is also available
Scope Note: DNA-binding domains present in proteins of the HMG-box superfamily including the archetypal HMGB PROTEINS, a number of sequence specific TRANSCRIPTION FACTORS, and other DNA-BINDING PROTEINS. The domains consist of 70-80 amino acids that form an L-shaped fold from three alpha-helical segments. The domain has the capacity to recognize and/or induce specific DNA structures and effect the accessibility of the DNA to other proteins involved in transcription, recombination, or DNA repair. (Note that not all HIGH MOBILITY GROUP PROTEINS contain this domain.)
Entry Term(s): HMG-1-Box Domain; HMG-Box Domain; High Mobility Group-Box Domains
Previous Indexing: High Mobility Group Proteins (1991-2001)
Public MeSH Note: 2002
History Note: 2002
Date Established: 2002/01/01
Date of Entry: 2001/08/03
Revision Date: 2016/05/31

Allowable Qualifiers: drug effects (DE)

genetics (GE)

immunology (IM)

physiology (PH)

radiation effects (RE)

Concept UI: M0371731
Scope Note: DNA-binding domains present in proteins of the HMG-box superfamily including the archetypal HMGB PROTEINS, a number of sequence specific TRANSCRIPTION FACTORS, and other DNA-BINDING PROTEINS. The domains consist of 70-80 amino acids that form an L-shaped fold from three alpha-helical segments. The domain has the capacity to recognize and/or induce specific DNA structures and effect the accessibility of the DNA to other proteins involved in transcription, recombination, or DNA repair. (Note that not all HIGH MOBILITY GROUP PROTEINS contain this domain.)
Terms: HMG-Box Domains Preferred Term
Term UI T427491
Date10/30/2000
LexicalTag ACX
ThesaurusID NLM (2002); HMG-1-Box Domain
Term UI T427529
Date10/30/2000
LexicalTag ACX
ThesaurusID NLM (2002); High Mobility Group-Box Domains
Term UI T427530
Date10/30/2000
LexicalTag NON
ThesaurusID NLM (2002); HMG-Box Domain
Term UI T717368
Date04/03/2008
LexicalTag ABX
ThesaurusID NLM (2009)

HMG-Box Domains MeSH Descriptor Data 2025