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C2 Domains MeSH Descriptor Data 2023


MeSH Heading
C2 Domains
Tree Number(s)
G02.111.570.820.709.275.750.125
Unique ID
D000070538
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D000070538
Scope Note
Protein modules that function in the targeting of proteins to CELL MEMBRANES. They consist of an eight-stranded anti-parallel beta-sandwich composed of a pair of four-stranded beta-sheets. This structural unit forms a pocket on the membrane-interacting face of the protein and co-ordinates the binding of 2 to 3 calcium ions; however, not all C2 domains bind calcium. Examples of C2 domain-containing proteins include PROTEIN KINASE C and PTEN PHOSPHOHYDROLASE.
Entry Term(s)
C2 Domain
C2 Tensin-type Domain
Previous Indexing
Amino Acid Sequence (1990-2016)
Protein Binding (1990-2016)
Public MeSH Note
2017
History Note
2017
Date Established
2017/01/01
Date of Entry
2016/07/08
Revision Date
2016/05/09
C2 Domains Preferred
C2 Tensin-type Domain Narrower
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