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PR-SET Domains MeSH Descriptor Data 2023


MeSH Heading
PR-SET Domains
Tree Number(s)
G02.111.570.820.709.275.750.477
Unique ID
D000074463
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D000074463
Scope Note
Highly conserved protein domains of approximately 130 to 140 amino acids. The SET domain was first identified in the Drosophila proteins (S)u(var)3-9, (E)nhancer-of-zeste and (T)rithorax and occurs in other proteins with a variety of functions, including histone-lysine N-methyltransferases. Structurally, it consists of BETA-SHEETS interspersed among loops and turns that result in an "L" shape. The most conserved motifs are a stretch at the C-terminal that contains a strictly conserved tyrosine residue and an adjacent loop that the C-terminal segment passes through to form a "knot". These motifs and especially the tyrosine residue are essential for S-ADENOSYLMETHIONINE binding and catalysis. The PR domain has high homology to the catalytic region of the SET domain and occurs at the N-terminal of PRDM proteins such as PRDM1 PROTEIN.
Entry Term(s)
PR Domain
SET Domain
Previous Indexing
Amino Acid Sequence (1996-2017)
Histone-Lysine N-Methyltransferase (1996-2017)
Public MeSH Note
2018
History Note
2018
Date Established
2018/01/01
Date of Entry
2017/07/11
Revision Date
2017/04/05
PR-SET Domains Preferred
SET Domain Narrower
PR Domain Narrower
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