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PR-SET Domains MeSH Descriptor Data 2023

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PR-SET Domains
Tree Number(s)
Unique ID
RDF Unique Identifier
Scope Note
Highly conserved protein domains of approximately 130 to 140 amino acids. The SET domain was first identified in the Drosophila proteins (S)u(var)3-9, (E)nhancer-of-zeste and (T)rithorax and occurs in other proteins with a variety of functions, including histone-lysine N-methyltransferases. Structurally, it consists of BETA-SHEETS interspersed among loops and turns that result in an "L" shape. The most conserved motifs are a stretch at the C-terminal that contains a strictly conserved tyrosine residue and an adjacent loop that the C-terminal segment passes through to form a "knot". These motifs and especially the tyrosine residue are essential for S-ADENOSYLMETHIONINE binding and catalysis. The PR domain has high homology to the catalytic region of the SET domain and occurs at the N-terminal of PRDM proteins such as PRDM1 PROTEIN.
Entry Term(s)
PR Domain
SET Domain
Previous Indexing
Amino Acid Sequence (1996-2017)
Histone-Lysine N-Methyltransferase (1996-2017)
Public MeSH Note
History Note
Date Established
Date of Entry
Revision Date
PR-SET Domains Preferred
SET Domain Narrower
PR Domain Narrower
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