MeSH Browser

MeSH Heading: Positive Regulatory Domain I-Binding Factor 1
Tree Number(s): D08.811.913.555.500.800.700; D12.776.260.703.650; D12.776.930.780.904
Unique ID: D000074462
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000074462
Scope Note: A transcriptional repressor protein that contains an N-terminal PR-SET domain, four C-terminal CYS2-HIS2 ZINC FINGERS, and binds the PRDI element in the INTERFERON-BETA gene. It has methyltransferase activity and mediates gene transcription in tissue-specific innate and adaptive immune lymphocyte T-CELLS, repressing expression of proteins that promote exit of these tissue-specific T-cell populations from non-lymphoid organs.
Entry Term(s): B Lymphocyte-Induced Maturation Protein 1; BLIMP1 Protein; PRDI-BF1 Protein; PRDM1 Protein
Previous Indexing: Repressor Proteins (1994-2017)
See Also: PR-SET Domains
Public MeSH Note: 2018
History Note: 2018
Date Established: 2018/01/01
Date of Entry: 2017/07/11
Revision Date: 2017/06/02

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M000626717
Scope Note: A transcriptional repressor protein that contains an N-terminal PR-SET domain, four C-terminal CYS2-HIS2 ZINC FINGERS, and binds the PRDI element in the INTERFERON-BETA gene. It has methyltransferase activity and mediates gene transcription in tissue-specific innate and adaptive immune lymphocyte T-CELLS, repressing expression of proteins that promote exit of these tissue-specific T-cell populations from non-lymphoid organs.
Terms: Positive Regulatory Domain I-Binding Factor 1 Preferred Term
Term UI T000916161
Date02/22/2017
LexicalTag NON
ThesaurusID NLM (2018); PRDM1 Protein
Term UI T000916162
Date02/22/2017
LexicalTag ABX
ThesaurusID NLM (2018); BLIMP1 Protein
Term UI T000916163
Date02/22/2017
LexicalTag ACX
ThesaurusID NLM (2018); B Lymphocyte-Induced Maturation Protein 1
Term UI T000916164
Date02/22/2017
LexicalTag NON
ThesaurusID NLM (2018); PRDI-BF1 Protein
Term UI T000916165
Date02/22/2017
LexicalTag ABX
ThesaurusID NLM (2018)

Positive Regulatory Domain I-Binding Factor 1 MeSH Descriptor Data 2025