MeSH Browser

MeSH Heading: Zinc Finger E-box Binding Homeobox 2
Tree Number(s): D12.776.260.400.883; D12.776.260.703.700; D12.776.930.780.918
Unique ID: D000074165
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000074165
Scope Note: A transcription factor that consists of 8 CYS2-HIS2 ZINC FINGERS flanking a central HOMEOBOX. It binds to the 5'-CACCT-3' DNA sequence located within E-BOX ELEMENTS of many genes essential for embryonic growth and development and regulates their activity; it represses transcription of the E-CADHERIN gene. Mutations in the ZEB2 gene are associated with MOWAT-WILSON SYNDROME.
Entry Term(s): Smad-Interacting Protein 1; Zeb2 Transcription Factor; Zinc Finger E-box Binding Homeobox 2 Protein
Previous Indexing: Homeodomain Proteins (2004-2017); Repressor Proteins (2004-2017)
Public MeSH Note: 2018
History Note: 2018
Date Established: 2018/01/01
Date of Entry: 2017/07/11
Revision Date: 2017/02/27

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M000625738
Scope Note: A transcription factor that consists of 8 CYS2-HIS2 ZINC FINGERS flanking a central HOMEOBOX. It binds to the 5'-CACCT-3' DNA sequence located within E-BOX ELEMENTS of many genes essential for embryonic growth and development and regulates their activity; it represses transcription of the E-CADHERIN gene. Mutations in the ZEB2 gene are associated with MOWAT-WILSON SYNDROME.
Terms: Zinc Finger E-box Binding Homeobox 2 Preferred Term
Term UI T000914397
Date01/19/2017
LexicalTag ABX
ThesaurusID NLM (2018); Zeb2 Transcription Factor
Term UI T000914403
Date01/19/2017
LexicalTag ABX
ThesaurusID NLM (2018); Smad-Interacting Protein 1
Term UI T000914393
Date01/19/2017
LexicalTag ABX
ThesaurusID NLM (2018); Zinc Finger E-box Binding Homeobox 2 Protein
Term UI T000914388
Date01/19/2017
LexicalTag NON
ThesaurusID NLM (2018)

Zinc Finger E-box Binding Homeobox 2 MeSH Descriptor Data 2025