MeSH Browser

MeSH Heading: Cadherins
Tree Number(s): D09.400.430.890.200.200; D12.776.395.550.200.200; D12.776.543.550.200.200; D23.050.301.350.200
Unique ID: D015820
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D015820
Scope Note: Calcium-dependent cell adhesion proteins. They are important in the formation of ADHERENS JUNCTIONS between cells. Cadherins are classified by their distinct immunological and tissue specificities, either by letters (E- for epithelial, N- for neural, and P- for placental cadherins) or by numbers (cadherin-12 or N-cadherin 2 for brain-cadherin). Cadherins promote cell adhesion via a homophilic mechanism as in the construction of tissues and of the whole animal body.
Entry Term(s): Cadherin; Cadherin-1; Cadherin-2; Cadherin-3; E-Cadherin; E-Cadherins; Epithelial-Cadherin; Epithelial-Cadherins; Liver Cell Adhesion Molecule; Liver Cell Adhesion Molecules; N-Cadherin; N-Cadherins; Neural Cadherin; Neural Cadherins; P-Cadherin; P-Cadherins; Placental Cadherins; Uvomorulin
Registry Numbers: 0
Previous Indexing: Antigens, Surface (1979-1989); Calcium-Binding Proteins (1980-1989); Glycoproteins (1966-1987); Membrane Glycoproteins (1988-1989)
Public MeSH Note: 90; N CADHERIN was indexed under CADHERINS 1994-95; LIVER CELL ADHESION MOLECULES was see CELL ADHESION MOLECULES 1990-95
Online Note: use CADHERINS (NM) to search N CADHERIN 1994-95; use CELL ADHESION MOLECULES to search LIVER CELL ADHESION MOLECULES 1990-95
History Note: 90; N CADHERIN was NM 1994-95; LIVER CELL ADHESION MOLECULES was see CELL ADHESION MOLECULES 1990-95
Date Established: 1990/01/01
Date of Entry: 1989/05/25
Revision Date: 2023/03/16

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Carbohydrates [D09]
- Glycoconjugates [D09.400]
  - Glycoproteins [D09.400.430]
    - Membrane Glycoproteins [D09.400.430.890]
      - Cell Adhesion Molecules [D09.400.430.890.200]
        
        12E7 Antigen [D09.400.430.890.200.049]
        
        CD11 Antigens [D09.400.430.890.200.074]
        
        CD24 Antigen [D09.400.430.890.200.098]
        
        CEACAM1 Protein [D09.400.430.890.200.107]
        
        Cell Adhesion Molecule-1 [D09.400.430.890.200.115]
        
        Nectins [D09.400.430.890.200.123]
        
        Platelet Endothelial Cell Adhesion Molecule-1 [D09.400.430.890.200.131]
        
        CD146 Antigen [D09.400.430.890.200.170]
        
        Endolyn [D09.400.430.890.200.175]
        
        Cadherin Related Proteins [D09.400.430.890.200.188]
        
        Cadherins [D09.400.430.890.200.200]
        
        Desmosomal Cadherins [D09.400.430.890.200.200.500]
        
        Protocadherins [D09.400.430.890.200.200.750]
        
        Carcinoembryonic Antigen [D09.400.430.890.200.210]
        
        CD4 Immunoadhesins [D09.400.430.890.200.230]
        
        Cell Adhesion Molecules, Neuronal [D09.400.430.890.200.250]
        
        Epithelial Cell Adhesion Molecule [D09.400.430.890.200.263]
        
        Integrin alphaXbeta2 [D09.400.430.890.200.275]
        
        Intercellular Adhesion Molecule-1 [D09.400.430.890.200.450]
        
        Intercellular Adhesion Molecule-3 [D09.400.430.890.200.494]
        
        Junctional Adhesion Molecules [D09.400.430.890.200.537]
        
        Receptors, Lymphocyte Homing [D09.400.430.890.200.625]
        
        Selectins [D09.400.430.890.200.700]
        
        Sialic Acid Binding Ig-like Lectin 2 [D09.400.430.890.200.810]
        
        Vascular Cell Adhesion Molecule-1 [D09.400.430.890.200.920]
        
        Vasodilator-Stimulated Phosphoprotein [D09.400.430.890.200.960]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Glycoproteins [D12.776.395]
    - Membrane Glycoproteins [D12.776.395.550]
      - Cell Adhesion Molecules [D12.776.395.550.200]
        
        12E7 Antigen [D12.776.395.550.200.049]
        
        CD11 Antigens [D12.776.395.550.200.074]
        
        CD24 Antigen [D12.776.395.550.200.098]
        
        CEACAM1 Protein [D12.776.395.550.200.107]
        
        Cell Adhesion Molecule-1 [D12.776.395.550.200.115]
        
        Nectins [D12.776.395.550.200.123]
        
        Platelet Endothelial Cell Adhesion Molecule-1 [D12.776.395.550.200.131]
        
        CD146 Antigen [D12.776.395.550.200.170]
        
        Endolyn [D12.776.395.550.200.175]
        
        Cadherin Related Proteins [D12.776.395.550.200.188]
        
        Cadherins [D12.776.395.550.200.200]
        
        Desmosomal Cadherins [D12.776.395.550.200.200.500]
        
        Protocadherins [D12.776.395.550.200.200.750]
        
        Carcinoembryonic Antigen [D12.776.395.550.200.210]
        
        CD4 Immunoadhesins [D12.776.395.550.200.230]
        
        Cell Adhesion Molecules, Neuronal [D12.776.395.550.200.250]
        
        Epithelial Cell Adhesion Molecule [D12.776.395.550.200.263]
        
        Integrin alphaXbeta2 [D12.776.395.550.200.275]
        
        Intercellular Adhesion Molecule-1 [D12.776.395.550.200.450]
        
        Intercellular Adhesion Molecule-3 [D12.776.395.550.200.494]
        
        Junctional Adhesion Molecules [D12.776.395.550.200.537]
        
        Receptors, Lymphocyte Homing [D12.776.395.550.200.625]
        
        Selectins [D12.776.395.550.200.700]
        
        Sialic Acid Binding Ig-like Lectin 2 [D12.776.395.550.200.810]
        
        Vascular Cell Adhesion Molecule-1 [D12.776.395.550.200.920]
        
        Vasodilator-Stimulated Phosphoprotein [D12.776.395.550.200.960]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Membrane Proteins [D12.776.543]
    - Membrane Glycoproteins [D12.776.543.550]
      - Cell Adhesion Molecules [D12.776.543.550.200]
        
        12E7 Antigen [D12.776.543.550.200.062]
        
        CD11 Antigens [D12.776.543.550.200.093]
        
        CD24 Antigen [D12.776.543.550.200.124]
        
        CEACAM1 Protein [D12.776.543.550.200.126]
        
        Cell Adhesion Molecule-1 [D12.776.543.550.200.128]
        
        Nectins [D12.776.543.550.200.130]
        
        Platelet Endothelial Cell Adhesion Molecule-1 [D12.776.543.550.200.131]
        
        CD146 Antigen [D12.776.543.550.200.140]
        
        Endolyn [D12.776.543.550.200.145]
        
        Cadherins [D12.776.543.550.200.200]
        
        Desmosomal Cadherins [D12.776.543.550.200.200.500]
        
        Protocadherins [D12.776.543.550.200.200.750]
        
        Carcinoembryonic Antigen [D12.776.543.550.200.210]
        
        CD4 Immunoadhesins [D12.776.543.550.200.230]
        
        Cell Adhesion Molecules, Neuronal [D12.776.543.550.200.250]
        
        Epithelial Cell Adhesion Molecule [D12.776.543.550.200.263]
        
        Integrin alphaXbeta2 [D12.776.543.550.200.275]
        
        Intercellular Adhesion Molecule-1 [D12.776.543.550.200.450]
        
        Intercellular Adhesion Molecule-3 [D12.776.543.550.200.494]
        
        Junctional Adhesion Molecules [D12.776.543.550.200.537]
        
        Receptors, Lymphocyte Homing [D12.776.543.550.200.625]
        
        Selectins [D12.776.543.550.200.700]
        
        Sialic Acid Binding Ig-like Lectin 2 [D12.776.543.550.200.810]
        
        Vascular Cell Adhesion Molecule-1 [D12.776.543.550.200.920]
        
        Vasodilator-Stimulated Phosphoprotein [D12.776.543.550.200.960]

Biological Factors [D23]
- Antigens [D23.050]
  - Antigens, Surface [D23.050.301]
    - Cell Adhesion Molecules [D23.050.301.350]

Cadherins Preferred

E-Cadherins Narrower

Concept UI: M0024235
Registry Numbers: 0
Terms: E-Cadherins Preferred Term
Term UI T046911
Date03/16/1989
LexicalTag NON
ThesaurusID NLM (1990); Uvomorulin
Term UI T046916
Date03/16/1989
LexicalTag NON
ThesaurusID NLM (1990); Cadherin-1
Term UI T666258
Date02/14/2006
LexicalTag NON
ThesaurusID NLM (2007); Epithelial-Cadherins
Term UI T666259
Date02/14/2006
LexicalTag NON
ThesaurusID NLM (2007); Epithelial-Cadherin
Term UI T001080075
Date05/11/2020
LexicalTag NON
ThesaurusID NLM (2021); E-Cadherin
Term UI T046910
Date03/20/1995
LexicalTag NON
ThesaurusID NLM (1996)

N-Cadherins Narrower

Concept UI: M0024236
Registry Numbers: 0
Terms: N-Cadherins Preferred Term
Term UI T046913
Date03/16/1989
LexicalTag NON
ThesaurusID NLM (1990); Neural Cadherins
Term UI T666260
Date02/14/2006
LexicalTag NON
ThesaurusID NLM (2007); Cadherin-2
Term UI T666261
Date02/14/2006
LexicalTag NON
ThesaurusID NLM (2007); Neural Cadherin
Term UI T001080076
Date05/11/2020
LexicalTag NON
ThesaurusID NLM (2021); N-Cadherin
Term UI T046912
Date03/20/1995
LexicalTag NON
ThesaurusID NLM (1996)

P-Cadherins Narrower

Concept UI: M0024237
Registry Numbers: 0
Terms: P-Cadherins Preferred Term
Term UI T046915
Date03/16/1989
LexicalTag NON
ThesaurusID NLM (1990); P-Cadherin
Term UI T046914
Date03/20/1995
LexicalTag NON
ThesaurusID NLM (1996); Placental Cadherins
Term UI T666262
Date02/14/2006
LexicalTag NON
ThesaurusID NLM (2007); Cadherin-3
Term UI T666263
Date02/14/2006
LexicalTag NON
ThesaurusID NLM (2007)

Liver Cell Adhesion Molecule Narrower

Cadherins MeSH Descriptor Data 2025