MeSH Browser

MeSH Heading: CD146 Antigen
Tree Number(s): D09.400.430.890.200.170; D12.776.395.550.200.170; D12.776.543.550.200.140; D12.776.624.301.249; D23.050.285.439.249; D23.050.301.350.150
Unique ID: D051929
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D051929
Scope Note: A cell adhesion molecule of the immunoglobulin superfamily that is expressed by ENDOTHELIAL CELLS where it functions to stabilize INTERCELLULAR JUNCTIONS. It is also highly expressed by melanoma tumor cells and may facilitate their METASTASIS.
Entry Term(s): Antigens, CD146; CD146 Antigens; Gicerin; Glycoprotein MUC18; Melanoma Cell Adhesion Molecule; S-Endo 1 Endothelial-Associated Antigen
See Also: Immunoglobulin Domains
Public MeSH Note: 2018; see ANTIGENS, CD146 2006-2017; CD146 ANTIGEN was indexed under CD ANTIGENS and NEURAL CELL ADHESION MOLECULES 2005; under MEMBRANE GLYCOPROTEINS 1990-2004; and under NEOPLASM PROTEINS 1993-2002
History Note: 2018 (1990)
Date Established: 2006/01/01
Date of Entry: 2005/06/30
Revision Date: 2023/03/16

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Carbohydrates [D09]
- Glycoconjugates [D09.400]
  - Glycoproteins [D09.400.430]
    - Membrane Glycoproteins [D09.400.430.890]
      - Cell Adhesion Molecules [D09.400.430.890.200]
        
        12E7 Antigen [D09.400.430.890.200.049]
        
        CD11 Antigens [D09.400.430.890.200.074]
        
        CD24 Antigen [D09.400.430.890.200.098]
        
        CEACAM1 Protein [D09.400.430.890.200.107]
        
        Cell Adhesion Molecule-1 [D09.400.430.890.200.115]
        
        Nectins [D09.400.430.890.200.123]
        
        Platelet Endothelial Cell Adhesion Molecule-1 [D09.400.430.890.200.131]
        
        CD146 Antigen [D09.400.430.890.200.170]
        
        Endolyn [D09.400.430.890.200.175]
        
        Cadherin Related Proteins [D09.400.430.890.200.188]
        
        Cadherins [D09.400.430.890.200.200]
        
        Carcinoembryonic Antigen [D09.400.430.890.200.210]
        
        CD4 Immunoadhesins [D09.400.430.890.200.230]
        
        Cell Adhesion Molecules, Neuronal [D09.400.430.890.200.250]
        
        Epithelial Cell Adhesion Molecule [D09.400.430.890.200.263]
        
        Integrin alphaXbeta2 [D09.400.430.890.200.275]
        
        Intercellular Adhesion Molecule-1 [D09.400.430.890.200.450]
        
        Intercellular Adhesion Molecule-3 [D09.400.430.890.200.494]
        
        Junctional Adhesion Molecules [D09.400.430.890.200.537]
        
        Receptors, Lymphocyte Homing [D09.400.430.890.200.625]
        
        Selectins [D09.400.430.890.200.700]
        
        Sialic Acid Binding Ig-like Lectin 2 [D09.400.430.890.200.810]
        
        Vascular Cell Adhesion Molecule-1 [D09.400.430.890.200.920]
        
        Vasodilator-Stimulated Phosphoprotein [D09.400.430.890.200.960]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Glycoproteins [D12.776.395]
    - Membrane Glycoproteins [D12.776.395.550]
      - Cell Adhesion Molecules [D12.776.395.550.200]
        
        12E7 Antigen [D12.776.395.550.200.049]
        
        CD11 Antigens [D12.776.395.550.200.074]
        
        CD24 Antigen [D12.776.395.550.200.098]
        
        CEACAM1 Protein [D12.776.395.550.200.107]
        
        Cell Adhesion Molecule-1 [D12.776.395.550.200.115]
        
        Nectins [D12.776.395.550.200.123]
        
        Platelet Endothelial Cell Adhesion Molecule-1 [D12.776.395.550.200.131]
        
        CD146 Antigen [D12.776.395.550.200.170]
        
        Endolyn [D12.776.395.550.200.175]
        
        Cadherin Related Proteins [D12.776.395.550.200.188]
        
        Cadherins [D12.776.395.550.200.200]
        
        Carcinoembryonic Antigen [D12.776.395.550.200.210]
        
        CD4 Immunoadhesins [D12.776.395.550.200.230]
        
        Cell Adhesion Molecules, Neuronal [D12.776.395.550.200.250]
        
        Epithelial Cell Adhesion Molecule [D12.776.395.550.200.263]
        
        Integrin alphaXbeta2 [D12.776.395.550.200.275]
        
        Intercellular Adhesion Molecule-1 [D12.776.395.550.200.450]
        
        Intercellular Adhesion Molecule-3 [D12.776.395.550.200.494]
        
        Junctional Adhesion Molecules [D12.776.395.550.200.537]
        
        Receptors, Lymphocyte Homing [D12.776.395.550.200.625]
        
        Selectins [D12.776.395.550.200.700]
        
        Sialic Acid Binding Ig-like Lectin 2 [D12.776.395.550.200.810]
        
        Vascular Cell Adhesion Molecule-1 [D12.776.395.550.200.920]
        
        Vasodilator-Stimulated Phosphoprotein [D12.776.395.550.200.960]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Membrane Proteins [D12.776.543]
    - Membrane Glycoproteins [D12.776.543.550]
      - Cell Adhesion Molecules [D12.776.543.550.200]
        
        12E7 Antigen [D12.776.543.550.200.062]
        
        CD11 Antigens [D12.776.543.550.200.093]
        
        CD24 Antigen [D12.776.543.550.200.124]
        
        CEACAM1 Protein [D12.776.543.550.200.126]
        
        Cell Adhesion Molecule-1 [D12.776.543.550.200.128]
        
        Nectins [D12.776.543.550.200.130]
        
        Platelet Endothelial Cell Adhesion Molecule-1 [D12.776.543.550.200.131]
        
        CD146 Antigen [D12.776.543.550.200.140]
        
        Endolyn [D12.776.543.550.200.145]
        
        Cadherins [D12.776.543.550.200.200]
        
        Carcinoembryonic Antigen [D12.776.543.550.200.210]
        
        CD4 Immunoadhesins [D12.776.543.550.200.230]
        
        Cell Adhesion Molecules, Neuronal [D12.776.543.550.200.250]
        
        Epithelial Cell Adhesion Molecule [D12.776.543.550.200.263]
        
        Integrin alphaXbeta2 [D12.776.543.550.200.275]
        
        Intercellular Adhesion Molecule-1 [D12.776.543.550.200.450]
        
        Intercellular Adhesion Molecule-3 [D12.776.543.550.200.494]
        
        Junctional Adhesion Molecules [D12.776.543.550.200.537]
        
        Receptors, Lymphocyte Homing [D12.776.543.550.200.625]
        
        Selectins [D12.776.543.550.200.700]
        
        Sialic Acid Binding Ig-like Lectin 2 [D12.776.543.550.200.810]
        
        Vascular Cell Adhesion Molecule-1 [D12.776.543.550.200.920]
        
        Vasodilator-Stimulated Phosphoprotein [D12.776.543.550.200.960]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Neoplasm Proteins [D12.776.624]
    - Melanoma-Specific Antigens [D12.776.624.301]

Biological Factors [D23]
- Antigens [D23.050]
  - Antigens, Neoplasm [D23.050.285]
    - Melanoma-Specific Antigens [D23.050.285.439]

Biological Factors [D23]
- Antigens [D23.050]
  - Antigens, Surface [D23.050.301]
    - Cell Adhesion Molecules [D23.050.301.350]

CD146 Antigen Preferred

Concept UI: M0172205
Scope Note: A cell adhesion molecule of the immunoglobulin superfamily that is expressed by ENDOTHELIAL CELLS where it functions to stabilize INTERCELLULAR JUNCTIONS. It is also highly expressed by melanoma tumor cells and may facilitate their METASTASIS.
Terms: CD146 Antigen Preferred Term
Term UI T609501
Date09/15/2004
LexicalTag NON
ThesaurusID NLM (2006); S-Endo 1 Endothelial-Associated Antigen
Term UI T287145
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2006); Melanoma Cell Adhesion Molecule
Term UI T411380
Date04/07/2000
LexicalTag NON
ThesaurusID NLM (2006); Glycoprotein MUC18
Term UI T202209
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2006); Antigens, CD146
Term UI T633918
Date03/21/2005
LexicalTag NON
ThesaurusID NLM (2006); Gicerin
Term UI T633919
Date03/21/2005
LexicalTag NON
ThesaurusID NLM (2006); CD146 Antigens
Term UI T636329
Date04/12/2005
LexicalTag NON
ThesaurusID NLM (2006)

CD146 Antigen MeSH Descriptor Data 2025