MeSH Browser

MeSH Heading: Zinc Finger E-box-Binding Homeobox 1
Tree Number(s): D12.776.260.400.906; D12.776.260.703.800; D12.776.930.780.945
Unique ID: D000071799
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000071799
Scope Note: A transcription factor characterized by N-terminal and C-terminal CYS2-HIS2 ZINC FINGERS separated by a homeobox. It represses the expression of E-CADHERIN to induce the EPITHELIAL-MESENCHYMAL TRANSITION. It also represses PROTO-ONCOGENE PROTEINS C-BCL-6; regulates the cell type-specific expression of SODIUM-POTASSIUM-EXCHANGING ATPASE; and promotes neuronal differentiation.
Entry Term(s): NIL-2-A Zinc Finger Protein; TCF8 Protein; Transcription Factor 8; Zeb1 Transcription Factor
Previous Indexing: Homeodomain Proteins (2004-2016); Transcription Factors (2004-2016)
Public MeSH Note: 2017
History Note: 2017
Date Established: 2017/01/01
Date of Entry: 2016/07/08
Revision Date: 2016/04/15

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Zinc Finger E-box-Binding Homeobox 1 MeSH Descriptor Data 2025