Because of a lapse in government funding, the information on this website may not be up to date, transactions submitted via the website may not be processed, and the agency may not be able to respond to inquiries until appropriations are enacted. The NIH Clinical Center (the research hospital of NIH) is open. For more details about its operating status, please visit cc.nih.gov. Updates regarding government operating status and resumption of normal operations can be found at opm.gov.

NLM Logo

Thyroid Nuclear Factor 1 MeSH Descriptor Data 2026


MeSH Heading
Thyroid Nuclear Factor 1
Tree Number(s)
D12.776.260.400.871
D12.776.660.823
D12.776.930.888
Unique ID
D000074482
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D000074482
Scope Note
A homeobox protein and transcription factor that localizes to the cell nucleus where it activates expression of thyroid specific genes such as THYROGLOBULIN and the THYROTROPIN RECEPTOR. It is critical for maintaining thyroid tissue in a differentiated state and also plays a role in lung development. Mutations in the NKX2-1 gene are associated with CHOREA, BENIGN HEREDITARY.
Entry Term(s)
Homeobox Protein Nkx-2.1
NK2 Homeobox 1 Protein
TITF-1 Protein
TITF1 Protein
TTF-1 Thyroid Nuclear Factor
Thyroid Transcription Factor 1
Thyroid-Specific Enhancer-Binding Protein
Registry Numbers
0
Public MeSH Note
2018; THYROID NUCLEAR FACTOR 1 was indexed under NUCLEAR PROTEINS and TRANSCRIPTION FACTORS 1990-2017
History Note
2018 (1990)
Date Introduced
2018/01/01
Last Updated
2018/01/01
Thyroid Nuclear Factor 1 Preferred
page delivered in 0.189s