MeSH Browser

MeSH Heading: Thyroid Nuclear Factor 1
Tree Number(s): D12.776.260.400.871; D12.776.660.823; D12.776.930.888
Unique ID: D000074482
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000074482
Scope Note: A homeobox protein and transcription factor that localizes to the cell nucleus where it activates expression of thyroid specific genes such as THYROGLOBULIN and the THYROTROPIN RECEPTOR. It is critical for maintaining thyroid tissue in a differentiated state and also plays a role in lung development. Mutations in the NKX2-1 gene are associated with CHOREA, BENIGN HEREDITARY.
Entry Term(s): Homeobox Protein Nkx-2.1; NK2 Homeobox 1 Protein; TITF-1 Protein; TITF1 Protein; TTF-1 Thyroid Nuclear Factor; Thyroid Transcription Factor 1; Thyroid-Specific Enhancer-Binding Protein
Registry Number: 0
Public MeSH Note: 2018; THYROID NUCLEAR FACTOR 1 was indexed under NUCLEAR PROTEINS and TRANSCRIPTION FACTORS 1990-2017
History Note: 2018 (1990)
Date Established: 2018/01/01
Date of Entry: 2017/07/11
Revision Date: 2017/04/06

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0181663
Registry Number: 0
Scope Note: A homeobox protein and transcription factor that localizes to the cell nucleus where it activates expression of thyroid specific genes such as THYROGLOBULIN and the THYROTROPIN RECEPTOR. It is critical for maintaining thyroid tissue in a differentiated state and also plays a role in lung development. Mutations in the NKX2-1 gene are associated with CHOREA, BENIGN HEREDITARY.
Terms: Thyroid Nuclear Factor 1 Preferred Term
Term UI T000916200
Date02/23/2017
LexicalTag NON
ThesaurusID NLM (1990); Thyroid Transcription Factor 1
Term UI T000916202
Date02/23/2017
LexicalTag NON
ThesaurusID NLM (1990); TITF-1 Protein
Term UI T000916210
Date02/23/2017
LexicalTag ABX
ThesaurusID NLM (2018); Homeobox Protein Nkx-2.1
Term UI T000916207
Date02/23/2017
LexicalTag ABX
ThesaurusID NLM (2018); NK2 Homeobox 1 Protein
Term UI T000916208
Date02/23/2017
LexicalTag ABX
ThesaurusID NLM (2018); TITF1 Protein
Term UI T000916209
Date02/23/2017
LexicalTag ABX
ThesaurusID NLM (2018); TTF-1 Thyroid Nuclear Factor
Term UI T000916201
Date02/23/2017
LexicalTag ABX
ThesaurusID NLM (2016); Thyroid-Specific Enhancer-Binding Protein
Term UI T000916204
Date02/23/2017
LexicalTag NON
ThesaurusID NLM (1990)

Thyroid Nuclear Factor 1 MeSH Descriptor Data 2023