MeSH Browser

MeSH Heading: p300-CBP Transcription Factors
Tree Number(s): D08.811.913.050.134.415.500.575; D12.776.930.680
Unique ID: D050880
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D050880
Scope Note: A family of histone acetyltransferases that is structurally-related to CREB-BINDING PROTEIN and to E1A-ASSOCIATED P300 PROTEIN. They function as transcriptional coactivators by bridging between DNA-binding TRANSCRIPTION FACTORS and the basal transcription machinery. They also modify transcription factors and CHROMATIN through ACETYLATION.
Entry Term(s): p300-CBP Coactivator; p300-CBP Protein
Public MeSH Note: 2006; P300/CBP PROTEINS was indexed under NUCLEAR PROTEINS & TRANS-ACTIVATORS 1999-2005
History Note: 2006(1994)
Date Established: 2006/01/01
Date of Entry: 2005/06/30
Revision Date: 2015/12/02

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

p300-CBP Transcription Factors MeSH Descriptor Data 2025