MeSH Browser

MeSH Heading: NFATC Transcription Factors
Tree Number(s): D12.776.930.608
Unique ID: D050778
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D050778
Scope Note: A family of transcription factors characterized by the presence of highly conserved calcineurin- and DNA-binding domains. NFAT proteins are activated in the CYTOPLASM by the calcium-dependent phosphatase CALCINEURIN. They transduce calcium signals to the nucleus where they can interact with TRANSCRIPTION FACTOR AP-1 or NF-KAPPA B and initiate GENETIC TRANSCRIPTION of GENES involved in CELL DIFFERENTIATION and development. NFAT proteins stimulate T-CELL activation through the induction of IMMEDIATE-EARLY GENES such as INTERLEUKIN-2.
Entry Term(s): NF-AT Proteins; NF-AT3 Protein; NF-AT4 Protein; NF-ATc1 Protein; NFAT Proteins; NFAT Transcription Factor 1; NFAT Transcription Factor 2; NFAT Transcription Factor 3; NFAT Transcription Factor 4; NFAT Transcription Factor 5; NFAT-1 Protein; NFAT-2 Protein; NFAT1 Protein; NFAT2 Protein; NFAT3 Protein; NFAT4 Protein; NFAT5 Protein; NFATC Proteins; NFATC1 Protein; NFATC1 Transcription Factor; NFATC2 Protein; NFATC2 Transcription Factor; NFATC3 Protein; NFATC3 Transcription Factor; NFATC4 Protein; NFATC4 Transcription Factor; NFATL1 Protein; NFATx Protein; NFATz Protein; Nuclear Factor of Activated T-Cells 5 Protein; Nuclear Factor of Activated T-Cells, Cytoplasmic; Nuclear Factor of Activated T-Cells, Cytoplasmic 1 Protein; Nuclear Factor of Activated T-Cells, Cytoplasmic 2 Protein; Nuclear Factor of Activated T-Cells, Cytoplasmic 3 Protein; Nuclear Factor of Activated T-Cells, Cytoplasmic 4 Protein; Nuclear Factors of Activated T-Cells; OREBP Protein; Osmotic Response Element Binding Protein; TonEBP Protein; Tonicity-Responsive Enhancer-Binding Protein; Transcription Factor NF-AT
Public MeSH Note: 2006; NFATC TRANSCRIPTION FACTORS was indexed under DNA-BINDING PROTEIN, NUCLEAR PROTEINS, & TRANSCRIPTION FACTORS 1993-2005
History Note: 2006(1993)
Date Established: 2006/01/01
Date of Entry: 2005/06/30
Revision Date: 2013/07/09

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Transcription Factors [D12.776.930]

NFATC Transcription Factors Preferred

Concept UI: M0212783
Scope Note: A family of transcription factors characterized by the presence of highly conserved calcineurin- and DNA-binding domains. NFAT proteins are activated in the CYTOPLASM by the calcium-dependent phosphatase CALCINEURIN. They transduce calcium signals to the nucleus where they can interact with TRANSCRIPTION FACTOR AP-1 or NF-KAPPA B and initiate GENETIC TRANSCRIPTION of GENES involved in CELL DIFFERENTIATION and development. NFAT proteins stimulate T-CELL activation through the induction of IMMEDIATE-EARLY GENES such as INTERLEUKIN-2.
Terms: NFATC Transcription Factors Preferred Term
Term UI T629655
Date02/03/2005
LexicalTag ABX
ThesaurusID NLM (2006); NFATC Proteins
Term UI T623933
Date12/14/2004
LexicalTag ABX
ThesaurusID NLM (2006); Nuclear Factor of Activated T-Cells, Cytoplasmic
Term UI T624047
Date12/14/2004
LexicalTag NON
ThesaurusID NLM (2006); NFAT Proteins
Term UI T623934
Date12/14/2004
LexicalTag ABX
ThesaurusID NLM (2006); Nuclear Factors of Activated T-Cells
Term UI T623932
Date12/14/2004
LexicalTag NON
ThesaurusID NLM (2006); Transcription Factor NF-AT
Term UI T242788
Date01/01/1955
LexicalTag ABX
ThesaurusID NLM (2006); NF-AT Proteins
Term UI T623935
Date12/14/2004
LexicalTag ABX
ThesaurusID NLM (2006)

NFAT Transcription Factor 3 Narrower

Concept UI: M0212771
Terms: NFAT Transcription Factor 3 Preferred Term
Term UI T633728
Date03/18/2005
LexicalTag ABX
ThesaurusID NLM (2006); Nuclear Factor of Activated T-Cells, Cytoplasmic 4 Protein
Term UI T624026
Date12/14/2004
LexicalTag NON
ThesaurusID NLM (2006); NF-AT3 Protein
Term UI T417616
Date06/23/2000
LexicalTag ABX
ThesaurusID NLM (2006); NFAT3 Protein
Term UI T407877
Date02/24/2000
LexicalTag ABX
ThesaurusID NLM (2006); NFATC4 Protein
Term UI T624025
Date12/14/2004
LexicalTag ABX
ThesaurusID NLM (2006); NFATC4 Transcription Factor
Term UI T629659
Date02/03/2005
LexicalTag ABX
ThesaurusID NLM (2006)

NFAT Transcription Factor 4 Narrower

Concept UI: M0212772
Terms: NFAT Transcription Factor 4 Preferred Term
Term UI T633727
Date03/18/2005
LexicalTag ABX
ThesaurusID NLM (2006); NFATC3 Transcription Factor
Term UI T629658
Date02/03/2005
LexicalTag ABX
ThesaurusID NLM (2006); NFATx Protein
Term UI T624037
Date12/14/2004
LexicalTag ABX
ThesaurusID NLM (2006); NFATC3 Protein
Term UI T624027
Date12/14/2004
LexicalTag ABX
ThesaurusID NLM (2006); NF-AT4 Protein
Term UI T624036
Date12/14/2004
LexicalTag ABX
ThesaurusID NLM (2006); NFAT4 Protein
Term UI T624038
Date12/14/2004
LexicalTag ABX
ThesaurusID NLM (2006); Nuclear Factor of Activated T-Cells, Cytoplasmic 3 Protein
Term UI T624028
Date12/14/2004
LexicalTag NON
ThesaurusID NLM (2006)

NFAT Transcription Factor 1 Narrower

Concept UI: M0212776
Terms: NFAT Transcription Factor 1 Preferred Term
Term UI T633726
Date03/18/2005
LexicalTag NON
ThesaurusID NLM (2006); Nuclear Factor of Activated T-Cells, Cytoplasmic 2 Protein
Term UI T624042
Date12/14/2004
LexicalTag NON
ThesaurusID NLM (2006); NFAT-1 Protein
Term UI T624040
Date12/14/2004
LexicalTag ABX
ThesaurusID NLM (2006); NFAT1 Protein
Term UI T624041
Date12/14/2004
LexicalTag ABX
ThesaurusID NLM (2006); NFATC2 Protein
Term UI T624039
Date12/14/2004
LexicalTag ABX
ThesaurusID NLM (2006); NFATC2 Transcription Factor
Term UI T629657
Date02/03/2005
LexicalTag ABX
ThesaurusID NLM (2006)

NFAT Transcription Factor 2 Narrower

Concept UI: M0328766
Terms: NFAT Transcription Factor 2 Preferred Term
Term UI T633725
Date03/18/2005
LexicalTag NON
ThesaurusID NLM (2006); NF-ATc1 Protein
Term UI T581794
Date04/07/2004
LexicalTag ABX
ThesaurusID NLM (2006); NFAT-2 Protein
Term UI T624044
Date12/14/2004
LexicalTag ABX
ThesaurusID NLM (2006); NFAT2 Protein
Term UI T624029
Date12/14/2004
LexicalTag ABX
ThesaurusID NLM (2006); NFATC1 Protein
Term UI T624043
Date12/14/2004
LexicalTag ABX
ThesaurusID NLM (2006); NFATC1 Transcription Factor
Term UI T629656
Date02/03/2005
LexicalTag ABX
ThesaurusID NLM (2006); Nuclear Factor of Activated T-Cells, Cytoplasmic 1 Protein
Term UI T624030
Date12/14/2004
LexicalTag NON
ThesaurusID NLM (2006)

NFAT Transcription Factor 5 Related

Concept UI: M0361472
Scope Note: A signal-dependent transcription factor that controls cellular response to osmotic stress. NFAT5 is closely related to NFATC PROTEINS but resides constitutively in the CELL NUCLEUS and operates independently of CALCINEURIN and TRANSCRIPTION FACTOR AP-1.
Terms: NFAT Transcription Factor 5 Preferred Term
Term UI T337109
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2006); Nuclear Factor of Activated T-Cells 5 Protein
Term UI T623987
Date12/14/2004
LexicalTag NON
ThesaurusID NLM (2006); OREBP Protein
Term UI T413143
Date05/02/2000
LexicalTag NON
ThesaurusID NLM (2006); Osmotic Response Element Binding Protein
Term UI T413142
Date05/02/2000
LexicalTag NON
ThesaurusID NLM (2006); TonEBP Protein
Term UI T624080
Date12/14/2004
LexicalTag NON
ThesaurusID NLM (2006); Tonicity-Responsive Enhancer-Binding Protein
Term UI T629717
Date02/04/2005
LexicalTag NON
ThesaurusID NLM (2006); NFAT5 Protein
Term UI T337110
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2006); NFATz Protein
Term UI T419651
Date07/22/2000
LexicalTag NON
ThesaurusID NLM (2006); NFATL1 Protein
Term UI T429915
Date11/29/2000
LexicalTag NON
ThesaurusID NLM (2006)

NFATC Transcription Factors MeSH Descriptor Data 2025