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NFATC Transcription Factors MeSH Descriptor Data 2026


MeSH Heading
NFATC Transcription Factors
Tree Number(s)
D12.776.930.608
Unique ID
D050778
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D050778
Scope Note
A family of transcription factors characterized by the presence of highly conserved calcineurin- and DNA-binding domains. NFAT proteins are activated in the CYTOPLASM by the calcium-dependent phosphatase CALCINEURIN. They transduce calcium signals to the nucleus where they can interact with TRANSCRIPTION FACTOR AP-1 or NF-KAPPA B and initiate GENETIC TRANSCRIPTION of GENES involved in CELL DIFFERENTIATION and development. NFAT proteins stimulate T-CELL activation through the induction of IMMEDIATE-EARLY GENES such as INTERLEUKIN-2.
Entry Term(s)
NF-AT Proteins
NF-AT3 Protein
NF-AT4 Protein
NF-ATc1 Protein
NFAT Proteins
NFAT Transcription Factor 1
NFAT Transcription Factor 2
NFAT Transcription Factor 3
NFAT Transcription Factor 4
NFAT Transcription Factor 5
NFAT-1 Protein
NFAT-2 Protein
NFAT1 Protein
NFAT2 Protein
NFAT3 Protein
NFAT4 Protein
NFAT5 Protein
NFATC Proteins
NFATC1 Protein
NFATC1 Transcription Factor
NFATC2 Protein
NFATC2 Transcription Factor
NFATC3 Protein
NFATC3 Transcription Factor
NFATC4 Protein
NFATC4 Transcription Factor
NFATL1 Protein
NFATx Protein
NFATz Protein
Nuclear Factor of Activated T-Cells 5 Protein
Nuclear Factor of Activated T-Cells, Cytoplasmic
Nuclear Factor of Activated T-Cells, Cytoplasmic 1 Protein
Nuclear Factor of Activated T-Cells, Cytoplasmic 2 Protein
Nuclear Factor of Activated T-Cells, Cytoplasmic 3 Protein
Nuclear Factor of Activated T-Cells, Cytoplasmic 4 Protein
Nuclear Factors of Activated T-Cells
OREBP Protein
Osmotic Response Element Binding Protein
TonEBP Protein
Tonicity-Responsive Enhancer-Binding Protein
Transcription Factor NF-AT
Registry Numbers
0
Public MeSH Note
2006; NFATC TRANSCRIPTION FACTORS was indexed under DNA-BINDING PROTEIN, NUCLEAR PROTEINS, & TRANSCRIPTION FACTORS 1993-2005
History Note
2006(1993)
Date Introduced
2006/01/01
Last Updated
2013/07/09
NFATC Transcription Factors Preferred
NFAT Transcription Factor 3 Narrower
NFAT Transcription Factor 4 Narrower
NFAT Transcription Factor 1 Narrower
NFAT Transcription Factor 2 Narrower
NFAT Transcription Factor 5 Related
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