MeSH Browser

MeSH Heading: Promyelocytic Leukemia Protein
Tree Number(s): D12.776.624.776.654; D12.776.660.745; D12.776.930.713; D12.776.934.500
Unique ID: D000071156
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000071156
Scope Note: A tripartite motif protein that contains three ZINC FINGERS, including a RING FINGER DOMAIN, at its N-terminal. Several nuclear and one cytoplasmic isoforms result from alternative splicing of the PML gene; most nuclear isoforms localize to subnuclear structures (PML nuclear bodies) that are disrupted in ACUTE PROMYELOCYTIC LEUKEMIA cells.
Entry Term(s): RNF71 Protein; TRIM19 Protein
Registry Number: 0
Previous Indexing: Nuclear Proteins (2008-2016); Transcription Factors (2008-2016); Tumor Suppressor Proteins (2008-2016)
Public MeSH Note: 2017
History Note: 2017
Date Established: 2017/01/01
Date of Entry: 2016/07/08
Revision Date: 2016/02/26

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M000613226
Registry Number: 0
Scope Note: A tripartite motif protein that contains three ZINC FINGERS, including a RING FINGER DOMAIN, at its N-terminal. Several nuclear and one cytoplasmic isoforms result from alternative splicing of the PML gene; most nuclear isoforms localize to subnuclear structures (PML nuclear bodies) that are disrupted in ACUTE PROMYELOCYTIC LEUKEMIA cells.
Terms: Promyelocytic Leukemia Protein Preferred Term
Term UI T000892948
Date12/31/2015
LexicalTag NON
ThesaurusID NLM (2017); RNF71 Protein
Term UI T000892951
Date12/31/2015
LexicalTag ABX
ThesaurusID NLM (2017); TRIM19 Protein
Term UI T000892950
Date12/31/2015
LexicalTag ABX
ThesaurusID NLM (2017)

Promyelocytic Leukemia Protein MeSH Descriptor Data 2023