MeSH Browser

MeSH Heading: Retinoblastoma Protein
Tree Number(s): D12.776.260.704; D12.776.624.776.745; D12.776.660.807; D12.776.744.770
Unique ID: D016160
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D016160
Annotation: /biosyn /‌drug eff /‌physiol /‌ultrastruct permitted
Scope Note: Product of the retinoblastoma tumor suppressor gene. It is a nuclear phosphoprotein hypothesized to normally act as an inhibitor of cell proliferation. Rb protein is absent in retinoblastoma cell lines. It also has been shown to form complexes with the adenovirus E1A protein, the SV40 T antigen, and the human papilloma virus E7 protein.
Entry Term(s): Rb Gene Product; Rb Protein; Rb1 Gene Product; Retinoblastoma Nuclear Phosphoprotein p105-Rb; p105-Rb Protein
Previous Indexing: Phosphoproteins (1990)
Public MeSH Note: 91
History Note: 91
Date Established: 1991/01/01
Date of Entry: 1990/06/19
Revision Date: 2005/06/30

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0024673
Scope Note: Product of the retinoblastoma tumor suppressor gene. It is a nuclear phosphoprotein hypothesized to normally act as an inhibitor of cell proliferation. Rb protein is absent in retinoblastoma cell lines. It also has been shown to form complexes with the adenovirus E1A protein, the SV40 T antigen, and the human papilloma virus E7 protein.
Terms: Retinoblastoma Protein Preferred Term
Term UI T047986
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1991); Rb Gene Product
Term UI T047984
Date02/01/1990
LexicalTag NON
ThesaurusID NLM (1991); Rb Protein
Term UI T047987
Date02/26/1990
LexicalTag NON
ThesaurusID NLM (1991); Rb1 Gene Product
Term UI T047985
Date02/01/1990
LexicalTag NON
ThesaurusID NLM (1991)

Retinoblastoma Protein MeSH Descriptor Data 2025