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Synapsins MeSH Descriptor Data 2025


MeSH Heading
Synapsins
Tree Number(s)
D12.776.631.750
D12.776.744.840
Unique ID
D016704
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D016704
Scope Note
A family of synaptic vesicle-associated proteins involved in the short-term regulation of NEUROTRANSMITTER release. Synapsin I, the predominant member of this family, links SYNAPTIC VESICLES to ACTIN FILAMENTS in the presynaptic nerve terminal. These interactions are modulated by the reversible PHOSPHORYLATION of synapsin I through various signal transduction pathways. The protein is also a substrate for cAMP- and CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASES. It is believed that these functional properties are also shared by synapsin II.
Entry Term(s)
Synapsin
Synapsin I
Synapsin II
Synapsin III
Previous Indexing
Nerve Tissue Proteins (1966-1991)
Neuropeptides (1987-1991)
Phosphoproteins (1970-1991)
Public MeSH Note
1992
History Note
1992; use SYNAPSINS (NM) 1981-1991
Date Established
1992/01/01
Date of Entry
1991/07/12
Revision Date
2020/05/27
Synapsins Preferred
Synapsin III Narrower
Synapsin I Narrower
Synapsin II Narrower
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