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Dysbindin MeSH Descriptor Data 2023


MeSH Heading
Dysbindin
Tree Number(s)
D12.776.210.500.410.250
D12.776.220.362.125
D12.776.543.268.250
D12.776.543.990.447
D12.776.631.262
Unique ID
D000074765
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D000074765
Scope Note
A dystrophin-associated protein and component of the Biogenesis of Lysosomal Organelles Complex-1 (BLOC-1 complex) which is essential for the formation of LYSOSOME - derived organelles such as platelet dense granules and MELANOSOMES. DTNBP1 is expressed primarily in the brain and neurons, where it functions with ADAPTOR PROTEIN COMPLEX 3 to transport membrane proteins to NEURITES and nerve terminals. It also regulates the release of neurotransmitters, transport of synaptic vesicles, and localization of DOPAMINE D2 RECEPTORS. Mutations in the DTNBP1 gene are associated with Type 7 HERMANSKY-PUDLAK SYNDROME and SCHIZOPHRENIA.
Entry Term(s)
DTNBP1 Protein
Dysbindin-1
Dystrobrevin Binding Protein 1
Hermansky-Pudlak Syndrome 7 Protein
Registry Number
0
Previous Indexing
Dystrophin-Associated Proteins (2001-2017)
Public MeSH Note
2018
History Note
2018
Date Established
2018/01/01
Date of Entry
2017/07/11
Revision Date
2017/04/05
Dysbindin Preferred
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