MeSH Browser

MeSH Heading: Dynamins
Tree Number(s): D08.811.277.040.330.200; D12.776.220.600.450.200; D12.776.543.990.400
Unique ID: D034281
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D034281
Annotation: general or unspecified; prefer specifics
Scope Note: A family of high molecular weight GTP phosphohydrolases that play a direct role in vesicle transport. They associate with microtubule bundles (MICROTUBULES) and are believed to produce mechanical force via a process linked to GTP hydrolysis. This enzyme was formerly listed as EC 3.6.1.50.
Entry Term(s): Dephosphin; Dynamin; Dynamin K44A; Dynamin, Alanine44 Substituted With Lysine; Dynamin, Mutated Form, K44A; GTPase-Deficient Dynamin
Previous Indexing: Ca(2+) Mg(2+)-ATPase (1989-1994); GTP Phosphohydrolases (1994-2002)
Public MeSH Note: 2003; DYNAMIN (now DYNAMINS) was indexed under GTP PHOSPHOHYDROLASES 1 1994-2002 & CA(2+) MG(2+)-ATPASE 1989-1993
History Note: 2003; use DYNAMINS (NM) 1989-2002
Date Established: 2003/01/01
Date of Entry: 2002/07/03
Revision Date: 2005/06/30

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0356790
Scope Note: Dynamins that contain an alanine in position 44 instead of lysine. The amino acid substitution causes the protein to be GTPase-deficient and unable to function normally in the cell. GTPase-deficient dynamins are used experimentally to study dynamin function.
Terms: GTPase-Deficient Dynamin Preferred Term
Term UI T470926
Date11/26/2001
LexicalTag ACX
ThesaurusID NLM (2003); Dynamin K44A
Term UI T406803
Date02/09/2000
LexicalTag ACX
ThesaurusID NLM (2003); Dynamin, Alanine44 Substituted With Lysine
Term UI T470928
Date11/26/2001
LexicalTag NON
ThesaurusID NLM (2003); Dynamin, Mutated Form, K44A
Term UI T470927
Date11/26/2001
LexicalTag ACX
ThesaurusID NLM (2003)

Dynamins MeSH Descriptor Data 2025