CDC2 Protein Kinase MeSH Descriptor Data 2025

MeSH Heading: CDC2 Protein Kinase
Tree Number(s): D08.811.913.696.620.682.700.646.500.500.250; D08.811.913.696.620.682.700.646.500.984.500; D12.776.167.200.067.249; D12.776.167.200.580.500; D12.776.476.563.646.500.500.250; D12.776.476.563.646.500.984.500; D12.776.744.360
Unique ID: D016203
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D016203
Scope Note: Phosphoprotein with protein kinase activity that functions in the G2/M phase transition of the CELL CYCLE. It is the catalytic subunit of the MATURATION-PROMOTING FACTOR and complexes with both CYCLIN A and CYCLIN B in mammalian cells. The maximal activity of cyclin-dependent kinase 1 is achieved when it is fully dephosphorylated.
Entry Term(s): Cdk1 Protein Kinase; Cyclin-Dependent Kinase 1; Histone Kinase p34(cdc2); Protein p34cdc2; cdc2+ Protein; cdk1 Kinase; p34cdc2 Protein
Related Numbers: EC 2.7.11.22
Previous Indexing: Phosphoproteins (1987-1990)
Public MeSH Note: 2004; see PROTEIN P34CDC2 1991-2003
History Note: 2004(1991)
Date Established: 1991/01/01
Date of Entry: 1990/06/19
Revision Date: 2021/05/21

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Transferases [D08.811.913]
    - Phosphotransferases [D08.811.913.696]
      - Phosphotransferases (Alcohol Group Acceptor) [D08.811.913.696.620]
        
        Protein Kinases [D08.811.913.696.620.682]
        
        Protein Serine-Threonine Kinases [D08.811.913.696.620.682.700]
        
        Proline-Directed Protein Kinases [D08.811.913.696.620.682.700.646]
        
        Cyclin-Dependent Kinases [D08.811.913.696.620.682.700.646.500]
        
        CDC2-CDC28 Kinases [D08.811.913.696.620.682.700.646.500.500]
        
        CDC2 Protein Kinase [D08.811.913.696.620.682.700.646.500.500.250]
        
        CDC28 Protein Kinase, S cerevisiae [D08.811.913.696.620.682.700.646.500.500.375]
        
        Cyclin-Dependent Kinase 5 [D08.811.913.696.620.682.700.646.500.500.500]
        
        Cyclin-Dependent Kinase 9 [D08.811.913.696.620.682.700.646.500.500.750]

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Transferases [D08.811.913]
    - Phosphotransferases [D08.811.913.696]
      - Phosphotransferases (Alcohol Group Acceptor) [D08.811.913.696.620]
        
        Protein Kinases [D08.811.913.696.620.682]
        
        Protein Serine-Threonine Kinases [D08.811.913.696.620.682.700]
        
        Proline-Directed Protein Kinases [D08.811.913.696.620.682.700.646]
        
        Cyclin-Dependent Kinases [D08.811.913.696.620.682.700.646.500]
        
        Maturation-Promoting Factor [D08.811.913.696.620.682.700.646.500.984]
        
        CDC2 Protein Kinase [D08.811.913.696.620.682.700.646.500.984.500]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Cell Cycle Proteins [D12.776.167]
    - Cyclin-Dependent Kinases [D12.776.167.200]
      - CDC2-CDC28 Kinases [D12.776.167.200.067]
        
        CDC2 Protein Kinase [D12.776.167.200.067.249]
        
        CDC28 Protein Kinase, S cerevisiae [D12.776.167.200.067.500]
        
        Cyclin-Dependent Kinase 5 [D12.776.167.200.067.875]
        
        Cyclin-Dependent Kinase 9 [D12.776.167.200.067.900]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Cell Cycle Proteins [D12.776.167]
    - Cyclin-Dependent Kinases [D12.776.167.200]
      - Maturation-Promoting Factor [D12.776.167.200.580]
        
        CDC2 Protein Kinase [D12.776.167.200.580.500]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Intracellular Signaling Peptides and Proteins [D12.776.476]
    - Protein Serine-Threonine Kinases [D12.776.476.563]
      - Proline-Directed Protein Kinases [D12.776.476.563.646]
        
        Cyclin-Dependent Kinases [D12.776.476.563.646.500]
        
        CDC2-CDC28 Kinases [D12.776.476.563.646.500.500]
        
        CDC2 Protein Kinase [D12.776.476.563.646.500.500.250]
        
        CDC28 Protein Kinase, S cerevisiae [D12.776.476.563.646.500.500.375]
        
        Cyclin-Dependent Kinase 5 [D12.776.476.563.646.500.500.500]
        
        Cyclin-Dependent Kinase 9 [D12.776.476.563.646.500.500.750]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Intracellular Signaling Peptides and Proteins [D12.776.476]
    - Protein Serine-Threonine Kinases [D12.776.476.563]
      - Proline-Directed Protein Kinases [D12.776.476.563.646]
        
        Cyclin-Dependent Kinases [D12.776.476.563.646.500]
        
        Maturation-Promoting Factor [D12.776.476.563.646.500.984]
        
        CDC2 Protein Kinase [D12.776.476.563.646.500.984.500]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Phosphoproteins [D12.776.744]

CDC2 Protein Kinase Preferred

Concept UI: M0024739
Related Numbers: EC 2.7.11.22
Scope Note: Phosphoprotein with protein kinase activity that functions in the G2/M phase transition of the CELL CYCLE. It is the catalytic subunit of the MATURATION-PROMOTING FACTOR and complexes with both CYCLIN A and CYCLIN B in mammalian cells. The maximal activity of cyclin-dependent kinase 1 is achieved when it is fully dephosphorylated.
Terms: CDC2 Protein Kinase Preferred Term
Term UI T048185
Date02/21/1990
LexicalTag ACX
ThesaurusID NLM (1991); cdc2+ Protein
Term UI T048186
Date03/05/1990
LexicalTag ACX
ThesaurusID NLM (1991); Cyclin-Dependent Kinase 1
Term UI T048190
Date05/13/1997
LexicalTag NON
ThesaurusID NLM (1998); cdk1 Kinase
Term UI T525947
Date11/12/2002
LexicalTag ACX
ThesaurusID NLM (2004); Cdk1 Protein Kinase
Term UI T634001
Date03/22/2005
LexicalTag ABX
ThesaurusID NLM (2006)

p34cdc2 Protein Narrower

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