MeSH Browser

MeSH Heading: Maturation-Promoting Factor
Tree Number(s): D08.811.913.696.620.682.700.646.500.984; D12.776.167.200.580; D12.776.476.563.646.500.984
Unique ID: D016200
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D016200
Scope Note: Protein kinase that drives both the mitotic and meiotic cycles in all eukaryotic organisms. In meiosis it induces immature oocytes to undergo meiotic maturation. In mitosis it has a role in the G2/M phase transition. Once activated by CYCLINS; MPF directly phosphorylates some of the proteins involved in nuclear envelope breakdown, chromosome condensation, spindle assembly, and the degradation of cyclins. The catalytic subunit of MPF is PROTEIN P34CDC2.
Entry Version: MPF
Entry Term(s): Histone H1 Kinase, Growth-Associated; Histone H1 Kinase, M-Phase-Specific; M Phase-Promoting Factor; Mitosis-Promoting Factor
Registry Numbers: EC 2.7.11.22
Previous Indexing: Growth Substances (1979-1990)
See Also: Cyclins
Public MeSH Note: 91; HISTONE H1 KINASE, M-PHASE-SPECIFIC was HISTONE H1 KINASE, M PHASE-SPECIFIC 1991-93
History Note: 91; HISTONE H1 KINASE, M-PHASE-SPECIFIC was HISTONE H1 KINASE, M PHASE-SPECIFIC 1991-93
Date Established: 1991/01/01
Date of Entry: 1990/06/17
Revision Date: 2021/05/21

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

urine (UR)

Concept UI: M0024733
Registry Numbers: EC 2.7.11.22
Scope Note: Protein kinase that drives both the mitotic and meiotic cycles in all eukaryotic organisms. In meiosis it induces immature oocytes to undergo meiotic maturation. In mitosis it has a role in the G2/M phase transition. Once activated by CYCLINS; MPF directly phosphorylates some of the proteins involved in nuclear envelope breakdown, chromosome condensation, spindle assembly, and the degradation of cyclins. The catalytic subunit of MPF is PROTEIN P34CDC2.
Terms: Maturation-Promoting Factor Preferred Term
Term UI T048172
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1991); Histone H1 Kinase, Growth-Associated
Term UI T048169
Date02/21/1990
LexicalTag NON
ThesaurusID NLM (1991); Histone H1 Kinase, M-Phase-Specific
Term UI T048170
Date02/21/1990
LexicalTag NON
ThesaurusID NLM (1991); M Phase-Promoting Factor
Term UI T048171
Date02/21/1990
LexicalTag NON
ThesaurusID NLM (1991); Mitosis-Promoting Factor
Term UI T048173
Date02/21/1990
LexicalTag NON
ThesaurusID NLM (1991)

Maturation-Promoting Factor MeSH Descriptor Data 2025