MeSH Browser

MeSH Heading: DCC Receptor
Tree Number(s): D12.644.360.075.413; D12.776.476.075.413; D12.776.543.750.003.500; D12.776.624.776.021
Unique ID: D000075389
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000075389
Scope Note: A receptor for NETRIN-1 that contains four membrane distal (N-terminal) Ig-like C2 domains and six membrane proximal (C-terminal) fibronectin type III domains. It is expressed primarily in the nerve axons and differentiated intestinal cells and is required for AXON GUIDANCE, mediating axon attraction of neuronal GROWTH CONES; however, it may also trigger axon repulsion through association with the UNC5 netrin-1 receptor. DCC also induces APOPTOSIS when it is unbound from netrin-1. Deletions of the DCC gene are observed in tumor metastases and the protein is not expressed in undifferentiated COLORECTAL CARCINOMA cells.
Entry Term(s): DCC Tumor Suppressor Protein; DCC-Netrin-1 Receptor; Deleted in Colorectal Carcinoma Protein
Registry Number: 0
Previous Indexing: Receptors, Cell Surface (2005-2017); Tumor Suppressor Proteins (2005-2017)
Public MeSH Note: 2018
History Note: 2018
Date Established: 2018/01/01
Date of Entry: 2017/07/11
Revision Date: 2017/05/24

Allowable Qualifiers: administration & dosage (AD)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

physiology (PH)

radiation effects (RE)

therapeutic use (TU)

ultrastructure (UL)

Concept UI: M000630298
Registry Number: 0
Scope Note: A receptor for NETRIN-1 that contains four membrane distal (N-terminal) Ig-like C2 domains and six membrane proximal (C-terminal) fibronectin type III domains. It is expressed primarily in the nerve axons and differentiated intestinal cells and is required for AXON GUIDANCE, mediating axon attraction of neuronal GROWTH CONES; however, it may also trigger axon repulsion through association with the UNC5 netrin-1 receptor. DCC also induces APOPTOSIS when it is unbound from netrin-1. Deletions of the DCC gene are observed in tumor metastases and the protein is not expressed in undifferentiated COLORECTAL CARCINOMA cells.
Terms: DCC Receptor Preferred Term
Term UI T000922017
Date04/19/2017
LexicalTag ABX
ThesaurusID NLM (2018); DCC Tumor Suppressor Protein
Term UI T000922020
Date04/19/2017
LexicalTag ABX
ThesaurusID NLM (2018); Deleted in Colorectal Carcinoma Protein
Term UI T000922018
Date04/19/2017
LexicalTag NON
ThesaurusID NLM (2018); DCC-Netrin-1 Receptor
Term UI T000922019
Date04/19/2017
LexicalTag ABX
ThesaurusID NLM (2018)

DCC Receptor MeSH Descriptor Data 2023