MeSH Browser

MeSH Heading: MRE11 Homologue Protein
Tree Number(s): D08.811.277.352.335.350.650; D08.811.277.352.335.375.813; D08.811.277.352.355.325.600; D08.811.277.352.365.290.250; D12.776.157.687.495; D12.776.260.539; D12.776.660.720.495
Unique ID: D000076228
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000076228
Scope Note: A component of the MRN complex along with Rad50 and Nibrin. Together, these perform a critical function in the repair of DOUBLE-STRANDED DNA BREAKS; RECOMBINATIONAL DNA REPAIR; maintenance of TELOMERE integrity and MEIOSIS. MRE11, which contains a poly(ADP)-ribose binding motif and associates with PARP1, possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Mutations in the MRE11 gene are associated with ATAXIA-TELANGIECTASIA-like disorder 1.
Entry Term(s): MRE11A Protein; Meiotic Recombination 11 Homolog 1 Protein
Previous Indexing: DNA-Binding Proteins (1999-2017)
Public MeSH Note: 2018
History Note: 2018
Date Established: 2018/01/01
Date of Entry: 2017/07/11
Revision Date: 2017/06/29

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M000632480
Scope Note: A component of the MRN complex along with Rad50 and Nibrin. Together, these perform a critical function in the repair of DOUBLE-STRANDED DNA BREAKS; RECOMBINATIONAL DNA REPAIR; maintenance of TELOMERE integrity and MEIOSIS. MRE11, which contains a poly(ADP)-ribose binding motif and associates with PARP1, possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Mutations in the MRE11 gene are associated with ATAXIA-TELANGIECTASIA-like disorder 1.
Terms: MRE11 Homologue Protein Preferred Term
Term UI T000925796
Date05/31/2017
LexicalTag ABX
ThesaurusID NLM (2018); Meiotic Recombination 11 Homolog 1 Protein
Term UI T000925797
Date05/31/2017
LexicalTag NON
ThesaurusID NLM (2018); MRE11A Protein
Term UI T000925798
Date05/31/2017
LexicalTag ABX
ThesaurusID NLM (2018)

MRE11 Homologue Protein MeSH Descriptor Data 2025