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MRE11 Homologue Protein MeSH Descriptor Data 2023


MeSH Heading
MRE11 Homologue Protein
Tree Number(s)
D08.811.277.352.335.350.650
D08.811.277.352.335.375.813
D08.811.277.352.355.325.600
D08.811.277.352.365.290.250
D12.776.157.687.495
D12.776.260.539
D12.776.660.720.495
Unique ID
D000076228
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D000076228
Scope Note
A component of the MRN complex along with Rad50 and Nibrin. Together, these perform a critical function in the repair of DOUBLE-STRANDED DNA BREAKS; RECOMBINATIONAL DNA REPAIR; maintenance of TELOMERE integrity and MEIOSIS. MRE11, which contains a poly(ADP)-ribose binding motif and associates with PARP1, possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Mutations in the MRE11 gene are associated with ATAXIA-TELANGIECTASIA-like disorder 1.
Entry Term(s)
MRE11A Protein
Meiotic Recombination 11 Homolog 1 Protein
Registry Number
EC 3.1.-
Previous Indexing
DNA-Binding Proteins (1999-2017)
Public MeSH Note
2018
History Note
2018
Date Established
2018/01/01
Date of Entry
2017/07/11
Revision Date
2017/06/29
MRE11 Homologue Protein Preferred
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