MeSH Browser

MeSH Heading: Zinc Finger Nucleases
Tree Number(s): D08.811.277.352.335.350.925; D08.811.277.352.355.325.850; D12.776.828.300.990
Unique ID: D000075804
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000075804
Scope Note: Genetically engineered nucleases that cleave DNA at a defined distance from specific DNA sequences recognized by ZINC FINGER DNA-BINDING DOMAINS. They are composed of a DNA cleaving domain adapted from DNA endonucleases fused to a zinc finger DNA-binding domain.
Entry Term(s): Zinc Finger Nuclease; Zinc-Finger Nuclease; Zinc-Finger Nucleases
Previous Indexing: Endonucleases (2005-2017)
Public MeSH Note: 2018
History Note: 2018
Date Established: 2018/01/01
Date of Entry: 2017/07/11
Revision Date: 2020/05/27

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M000631470
Scope Note: Genetically engineered nucleases that cleave DNA at a defined distance from specific DNA sequences recognized by ZINC FINGER DNA-BINDING DOMAINS. They are composed of a DNA cleaving domain adapted from DNA endonucleases fused to a zinc finger DNA-binding domain.
Terms: Zinc Finger Nucleases Preferred Term
Term UI T000924142
Date05/11/2017
LexicalTag NON
ThesaurusID NLM (2018); Zinc-Finger Nuclease
Term UI T000998546
Date11/21/2019
LexicalTag NON
ThesaurusID NLM (2021); Zinc Finger Nuclease
Term UI T000998547
Date11/21/2019
LexicalTag NON
ThesaurusID NLM (2021); Zinc-Finger Nucleases
Term UI T000924133
Date05/11/2017
LexicalTag NON
ThesaurusID NLM (2018)

Zinc Finger Nucleases MeSH Descriptor Data 2025