Meiotic Recombination Protein SPO11 MeSH Descriptor Data 2026

MeSH Heading: Meiotic Recombination Protein SPO11
Tree Number(s): D08.811.277.352.335.350.675; D08.811.277.352.355.325.650
Unique ID: D000099257
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000099257
Scope Note: An endodeoxyribonuclease that functions as part of a DNA TOPOISOMERASE II complex to create DOUBLE-STRAND DNA BREAKS for initiating HOMOLOGOUS RECOMBINATION in MEIOSIS.
Public MeSH Note: 2026; MEIOTIC RECOMBINATION PROTEIN SPO11 was indexed under ENDODEOXYRIBONUCLEASES 2011-2025, and under ESTERASES 1999-2010
History Note: 2026 (1999)
Date Introduced: 2026/01/01
Last Updated: 2026/01/01

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Hydrolases [D08.811.277]
    - Esterases [D08.811.277.352]
      - Deoxyribonucleases [D08.811.277.352.335]
        
        Endodeoxyribonucleases [D08.811.277.352.335.350]
        
        Deoxyribonuclease (Pyrimidine Dimer) [D08.811.277.352.335.350.137]
        
        Deoxyribonuclease I [D08.811.277.352.335.350.250]
        
        Deoxyribonuclease IV (Phage T4-Induced) [D08.811.277.352.335.350.275]
        
        DNA Restriction Enzymes [D08.811.277.352.335.350.300]
        
        Holliday Junction Resolvases [D08.811.277.352.335.350.400]
        
        Micrococcal Nuclease [D08.811.277.352.335.350.500]
        
        Mismatch Repair Endonuclease PMS2 [D08.811.277.352.335.350.600]
        
        MRE11 Homologue Protein [D08.811.277.352.335.350.650]
        
        Meiotic Recombination Protein SPO11 [D08.811.277.352.335.350.675]
        
        Single-Strand Specific DNA and RNA Endonucleases [D08.811.277.352.335.350.700]
        
        Transcription Activator-Like Effector Nucleases [D08.811.277.352.335.350.850]
        
        Zinc Finger Nucleases [D08.811.277.352.335.350.925]

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Hydrolases [D08.811.277]
    - Esterases [D08.811.277.352]
      - Endonucleases [D08.811.277.352.355]
        
        Endodeoxyribonucleases [D08.811.277.352.355.325]
        
        CRISPR-Associated Protein 9 [D08.811.277.352.355.325.150]
        
        DNA Restriction Enzymes [D08.811.277.352.355.325.300]
        
        Flap Endonucleases [D08.811.277.352.355.325.350]
        
        Holliday Junction Resolvases [D08.811.277.352.355.325.400]
        
        Micrococcal Nuclease [D08.811.277.352.355.325.500]
        
        MRE11 Homologue Protein [D08.811.277.352.355.325.600]
        
        Meiotic Recombination Protein SPO11 [D08.811.277.352.355.325.650]
        
        Single-Strand Specific DNA and RNA Endonucleases [D08.811.277.352.355.325.700]
        
        Zinc Finger Nucleases [D08.811.277.352.355.325.850]

Meiotic Recombination Protein SPO11 Preferred

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