MeSH Browser

MeSH Heading: Mismatch Repair Endonuclease PMS2
Tree Number(s): D08.811.074.766.250; D08.811.277.040.025.215.250; D08.811.277.352.335.350.600; D12.776.260.540.250
Unique ID: D000070976
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000070976
Scope Note: A MutL protein and component of the DNA MISMATCH REPAIR system. Its ENDONUCLEASE activity introduces SINGLE-STRAND DNA BREAKS which create entry points for EXO1 exonuclease to remove the strand containing the mismatch. It may also function in DNA DAMAGE signaling.
Entry Term(s): PMS-2 Protein; PMS1 Homolog 2, Mismatch Repair Protein; PMS2 Protein; Postmeiotic Segregation Increased-S. cerevisiae-2
Previous Indexing: Adenosine Triphosphatases (2001-2016); DNA Repair Enzymes (2001-2016)
Public MeSH Note: 2017
History Note: 2017
Date Established: 2017/01/01
Date of Entry: 2016/07/08
Revision Date: 2016/03/01

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M000612774
Scope Note: A MutL protein and component of the DNA MISMATCH REPAIR system. Its ENDONUCLEASE activity introduces SINGLE-STRAND DNA BREAKS which create entry points for EXO1 exonuclease to remove the strand containing the mismatch. It may also function in DNA DAMAGE signaling.
Terms: Mismatch Repair Endonuclease PMS2 Preferred Term
Term UI T000892196
Date12/16/2015
LexicalTag ABX
ThesaurusID NLM (2017); PMS2 Protein
Term UI T000892197
Date12/16/2015
LexicalTag ABX
ThesaurusID NLM (2017); Postmeiotic Segregation Increased-S. cerevisiae-2
Term UI T000892198
Date12/16/2015
LexicalTag NON
ThesaurusID NLM (2017); PMS1 Homolog 2, Mismatch Repair Protein
Term UI T000892199
Date12/16/2015
LexicalTag ABX
ThesaurusID NLM (2017); PMS-2 Protein
Term UI T000892200
Date12/16/2015
LexicalTag ABX
ThesaurusID NLM (2017)

Mismatch Repair Endonuclease PMS2 MeSH Descriptor Data 2025