MeSH Browser

MeSH Heading: Deoxyribonuclease I
Tree Number(s): D08.811.277.352.335.350.250
Unique ID: D003850
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D003850
Annotation: do not confuse entry term STREPTODORNASE with STREPTODORNASE AND STREPTOKINASE
Scope Note: An enzyme capable of hydrolyzing highly polymerized DNA by splitting phosphodiester linkages, preferentially adjacent to a pyrimidine nucleotide. This catalyzes endonucleolytic cleavage of DNA yielding 5'-phosphodi- and oligonucleotide end-products. The enzyme has a preference for double-stranded DNA.
Entry Term(s): DNA Endonuclease; DNA Nicking Enzyme; DNAase I; DNase I; Dornavac; Endonuclease I; Nickase; Pancreatic DNase; Streptodornase; T4-Endonuclease II; T7-Endonuclease I; Thymonuclease
Previous Indexing: Deoxyribonucleases (1966-1982); Endodeoxyribonucleases (1983-1984); Endonucleases (1973-1982)
Public MeSH Note: 85; STREPTORDORNASE was see DEOXYRIBONUCLEASES 1966-93
Online Note: use DEOXYRIBONUCLEASES to search STREPTODORNASE 1966-93
History Note: 85; STREPTODORNASE was see DEOXYRIBONUCLEASES 1966-93
Date Established: 1985/01/01
Date of Entry: 1984/05/24
Revision Date: 2003/07/09

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0006007
Scope Note: An enzyme capable of hydrolyzing highly polymerized DNA by splitting phosphodiester linkages, preferentially adjacent to a pyrimidine nucleotide. This catalyzes endonucleolytic cleavage of DNA yielding 5'-phosphodi- and oligonucleotide end-products. The enzyme has a preference for double-stranded DNA.
Terms: Deoxyribonuclease I Preferred Term
Term UI T011445
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1985); DNase I
Term UI T011447
Date05/24/1984
LexicalTag NON
ThesaurusID UNK (19XX); Pancreatic DNase
Term UI T011449
Date05/24/1984
LexicalTag NON
ThesaurusID UNK (19XX); Thymonuclease
Term UI T011450
Date05/24/1984
LexicalTag NON
ThesaurusID UNK (19XX); DNAase I
Term UI T011451
Date05/24/1984
LexicalTag NON
ThesaurusID UNK (19XX); DNA Endonuclease
Term UI T011446
Date05/24/1984
LexicalTag NON
ThesaurusID UNK (19XX)

Deoxyribonuclease I MeSH Descriptor Data 2025