Alefacept MeSH Descriptor Data 2023

MeSH Heading: Alefacept
Tree Number(s): D12.776.124.486.485.114.619.393.131; D12.776.124.790.651.114.619.393.131; D12.776.377.715.548.114.619.393.131; D12.776.395.550.034.500; D12.776.543.550.158.500; D12.776.828.300.100
Unique ID: D000077944
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000077944
Scope Note: A recombinant human fusion protein of LFA-3 antigen and immunoglobulin IGG1 that binds to CD2 ANTIGENS on memory T-LYMPHOCYTES, preventing their activation and proliferation. It is used in the management of moderate to severe chronic plaque PSORIASIS.
Entry Term(s): Amevive; LFA-3 IgG(1) Fusion Protein; LFA-3 IgG1 Fusion Protein
Pharm Action: Dermatologic Agents
Immunologic Factors
Registry Number: ELK3V90G6C
Related Numbers: 222535-22-0
Public MeSH Note: 2019; ALEFACEPT was indexed under RECOMBINANT FUSION PROTEINS 2000-2018
History Note: 2019 (2000)
Date Established: 2019/01/01
Date of Entry: 2018/07/09
Revision Date: 2018/05/21

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Blood Proteins [D12.776.124]
    - Immunoproteins [D12.776.124.486]
      - Immunoglobulins [D12.776.124.486.485]
        
        Antibodies [D12.776.124.486.485.114]
        
        Immunoglobulin Isotypes [D12.776.124.486.485.114.619]
        
        Immunoglobulin G [D12.776.124.486.485.114.619.393]
        
        Alefacept [D12.776.124.486.485.114.619.393.131]
        
        Immunoglobulin gamma-Chains [D12.776.124.486.485.114.619.393.522]
        
        Immunoglobulins, Intravenous [D12.776.124.486.485.114.619.393.536]
        
        Long-Acting Thyroid Stimulator [D12.776.124.486.485.114.619.393.550]
        
        Muromonab-CD3 [D12.776.124.486.485.114.619.393.570]
        
        Rho(D) Immune Globulin [D12.776.124.486.485.114.619.393.700]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Blood Proteins [D12.776.124]
    - Serum Globulins [D12.776.124.790]
      - Immunoglobulins [D12.776.124.790.651]
        
        Antibodies [D12.776.124.790.651.114]
        
        Immunoglobulin Isotypes [D12.776.124.790.651.114.619]
        
        Immunoglobulin G [D12.776.124.790.651.114.619.393]
        
        Alefacept [D12.776.124.790.651.114.619.393.131]
        
        Immunoglobulin gamma-Chains [D12.776.124.790.651.114.619.393.522]
        
        Long-Acting Thyroid Stimulator [D12.776.124.790.651.114.619.393.550]
        
        Muromonab-CD3 [D12.776.124.790.651.114.619.393.570]
        
        Rho(D) Immune Globulin [D12.776.124.790.651.114.619.393.700]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Globulins [D12.776.377]
    - Serum Globulins [D12.776.377.715]
      - Immunoglobulins [D12.776.377.715.548]
        
        Antibodies [D12.776.377.715.548.114]
        
        Immunoglobulin Isotypes [D12.776.377.715.548.114.619]
        
        Immunoglobulin G [D12.776.377.715.548.114.619.393]
        
        Alefacept [D12.776.377.715.548.114.619.393.131]
        
        Immunoglobulin gamma-Chains [D12.776.377.715.548.114.619.393.522]
        
        Long-Acting Thyroid Stimulator [D12.776.377.715.548.114.619.393.550]
        
        Muromonab-CD3 [D12.776.377.715.548.114.619.393.570]
        
        Rho(D) Immune Globulin [D12.776.377.715.548.114.619.393.700]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Glycoproteins [D12.776.395]
    - Membrane Glycoproteins [D12.776.395.550]
      - CD58 Antigens [D12.776.395.550.034]
        
        Alefacept [D12.776.395.550.034.500]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Membrane Proteins [D12.776.543]
    - Membrane Glycoproteins [D12.776.543.550]
      - CD58 Antigens [D12.776.543.550.158]
        
        Alefacept [D12.776.543.550.158.500]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Recombinant Proteins [D12.776.828]
    - Recombinant Fusion Proteins [D12.776.828.300]

Alefacept Preferred

Concept UI: M0374901
Registry Number: ELK3V90G6C
Related Numbers: 222535-22-0
Scope Note: A recombinant human fusion protein of LFA-3 antigen and immunoglobulin IGG1 that binds to CD2 ANTIGENS on memory T-LYMPHOCYTES, preventing their activation and proliferation. It is used in the management of moderate to severe chronic plaque PSORIASIS.
Terms: Alefacept Preferred Term
Term UI T000941750
Date03/30/2018
LexicalTag NON
ThesaurusID; LFA-3 IgG1 Fusion Protein
Term UI T000941752
Date03/30/2018
LexicalTag NON
ThesaurusID NLM (2000); LFA-3 IgG(1) Fusion Protein
Term UI T000941751
Date03/30/2018
LexicalTag ABX
ThesaurusID NLM (2000)

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