MeSH Browser

MeSH Heading: Werner Syndrome Helicase
Tree Number(s): D08.811.277.040.025.159.249.500; D08.811.277.352.335.375.875; D08.811.277.352.365.290.500; D08.811.399.340.249.500; D12.776.157.687.750; D12.776.660.720.750
Unique ID: D000071657
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000071657
Scope Note: A DNA-dependent helicase and 3'-5' exonuclease. It has 3'->5' exonuclease activity towards double-stranded DNA with a 5'-overhang and binds preferentially to DNA substrates containing alternate secondary structures, such as replication forks and HOLLIDAY JUNCTIONS. Mutations in the WRN gene are associated with WERNER SYNDROME.
Entry Term(s): RECQ3 Protein; RECQL2 Protein; Werner Syndrome ATP-Dependent Helicase; Werner Syndrome RecQ-Like Helicase
Previous Indexing: Exodeoxyribonucleases (1996-2016); RecQ Helicases (2006-2016)
Public MeSH Note: 2017
History Note: 2017
Date Established: 2017/01/01
Date of Entry: 2016/07/08
Revision Date: 2017/05/24

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M000615275
Scope Note: A DNA-dependent helicase and 3'-5' exonuclease. It has 3'->5' exonuclease activity towards double-stranded DNA with a 5'-overhang and binds preferentially to DNA substrates containing alternate secondary structures, such as replication forks and HOLLIDAY JUNCTIONS. Mutations in the WRN gene are associated with WERNER SYNDROME.
Terms: Werner Syndrome Helicase Preferred Term
Term UI T000896252
Date03/01/2016
LexicalTag NON
ThesaurusID NLM (2017); Werner Syndrome RecQ-Like Helicase
Term UI T000896254
Date03/01/2016
LexicalTag ABX
ThesaurusID NLM (2017); RECQ3 Protein
Term UI T000896256
Date03/01/2016
LexicalTag ABX
ThesaurusID NLM (2017); RECQL2 Protein
Term UI T000896257
Date03/01/2016
LexicalTag ABX
ThesaurusID NLM (2017); Werner Syndrome ATP-Dependent Helicase
Term UI T000896253
Date03/01/2016
LexicalTag NON
ThesaurusID NLM (2017)

Werner Syndrome Helicase MeSH Descriptor Data 2025