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Proteins that catalyze the unwinding of duplex DNA during replication by binding cooperatively to single-stranded regions of DNA or to short regions of duplex DNA that are undergoing transient opening. In addition, DNA helicases are DNA-dependent ATPases that harness the free energy of ATP hydrolysis to translocate DNA strands.
Entry Term(s)
ATP-Dependent DNA Helicase
ATP-Dependent DNA Helicases
DNA Helicase
DNA Helicase A
DNA Helicase E
DNA Helicase II
DNA Helicase III
DNA Unwinding Protein
DNA Unwinding Proteins
Registry Numbers
EC 3.6.4.-
EC 3.6.4.12
EC 3.6.4.12
EC 3.6.4.12
EC 3.6.4.12
EC 3.6.4.12
Related Numbers
EC 3.6.4.12
NLM Classification #
QU 137
Previous Indexing
Deoxyribonucleases (1966-1977)
Endonucleases (1973-1977)
Proteins (1966-1977)
specific protein (1966-1977)
Public MeSH Note
1994; see DNA UNWINDING PROTEINS 1978-1993; for DNA HELICASE A, DNA HELICASE E, DNA HELICASE II were indexed under ADENOSINE TRIPHOSPHATASES & DNA HELICASES 1980-2006; DNA HELICASE III was indexed under DNA HELICASES 1981-2006 & under DNA GYRASE 1980-1981, & under DNA, SUPERHELICAL 1979-1980
Proteins that catalyze the unwinding of duplex DNA during replication by binding cooperatively to single-stranded regions of DNA or to short regions of duplex DNA that are undergoing transient opening. In addition, DNA helicases are DNA-dependent ATPases that harness the free energy of ATP hydrolysis to translocate DNA strands.