MeSH Browser

MeSH Heading: DNA Topoisomerases, Type I
Tree Number(s): D08.811.399.403.483; D12.776.157.687.375; D12.776.660.720.375
Unique ID: D004264
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D004264
Annotation: do not confuse entry term DNA UNTWISTING PROTEIN with DNA UNWINDING PROTEINS see DNA HELICASES; coordinate with BACTERIAL PROTEINS or ARCHAEAL PROTEINS if pertinent
Scope Note: DNA TOPOISOMERASES that catalyze ATP-independent breakage of one of the two strands of DNA, passage of the unbroken strand through the break, and rejoining of the broken strand. DNA Topoisomerases, Type I enzymes reduce the topological stress in the DNA structure by relaxing the superhelical turns and knotted rings in the DNA helix.
Entry Term(s): DNA Nicking-Closing Protein; DNA Nicking-Closing Proteins; DNA Relaxing Enzyme; DNA Relaxing Enzymes; DNA Relaxing Protein; DNA Topoisomerase; DNA Topoisomerase I; DNA Topoisomerase III; DNA Topoisomerase III alpha; DNA Topoisomerase III beta; DNA Type 1 Topoisomerase; DNA Untwisting Enzyme; DNA Untwisting Enzymes; DNA Untwisting Protein; DNA Untwisting Proteins; TOP3 Topoisomerase; TOP3alpha; TOPO IIIalpha; Topo III; Topoisomerase I; Topoisomerase III; Topoisomerase III beta; Topoisomerase IIIalpha; Topoisomerase IIIbeta; Type I DNA Topoisomerase
Registry Numbers: EC 5.99.1.2; 0
Related Numbers: 143180-75-0
CAS Type 1 Name: DNA topoisomerase
Previous Indexing: Deoxyribonucleases (1966-1977); DNA, Circular (1973-1977); Polynucleotide Synthetases (1973-1977); Proteins (1966-1977); specific protein (1966-1977)
Public MeSH Note: 2002; see DNA TOPOISOMERASE 1994-2001, see DNA UNTWISTING PROTEINS 1978-1993; for DNA NICKING-CLOSING PROTEIN see DNA NICKING-CLOSING PROTEINS 1978-1993; for DNA RELAXING ENZYME see DNA RELAXING ENZYMES 1978-1993; for DNA UNTWISTING ENZYME see DNA UNTWISTING ENZYMES 1978-1993
History Note: 2002
Entry Combination: antagonists & inhibitors:Topoisomerase I Inhibitors
Date Established: 1978/01/01
Date of Entry: 1977/04/15
Revision Date: 2019/07/08

Entry Combination: antagonists & inhibitors:Topoisomerase I Inhibitors
Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Isomerases [D08.811.399]
    - DNA Topoisomerases [D08.811.399.403]
      - DNA Topoisomerases, Type I [D08.811.399.403.483]
      - DNA Topoisomerases, Type II [D08.811.399.403.741]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Carrier Proteins [D12.776.157]
    - Poly-ADP-Ribose Binding Proteins [D12.776.157.687]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Nuclear Proteins [D12.776.660]
    - Poly-ADP-Ribose Binding Proteins [D12.776.660.720]

DNA Topoisomerases, Type I Preferred

Concept UI: M0381011
Registry Numbers: EC 5.99.1.2
Related Numbers: 143180-75-0
Scope Note: DNA TOPOISOMERASES that catalyze ATP-independent breakage of one of the two strands of DNA, passage of the unbroken strand through the break, and rejoining of the broken strand. DNA Topoisomerases, Type I enzymes reduce the topological stress in the DNA structure by relaxing the superhelical turns and knotted rings in the DNA helix.
Terms: DNA Topoisomerases, Type I Preferred Term
Term UI T439293
Date03/15/2001
LexicalTag NON
ThesaurusID NLM (2002); DNA Nicking-Closing Proteins
Term UI T012961
Date10/13/1992
LexicalTag NON
ThesaurusID NLM (1994); DNA Nicking-Closing Protein
Term UI T012962
Date10/13/1992
LexicalTag NON
ThesaurusID NLM (1994); DNA Relaxing Enzymes
Term UI T012963
Date10/14/1992
LexicalTag NON
ThesaurusID NLM (1994); DNA Relaxing Enzyme
Term UI T012964
Date10/13/1992
LexicalTag NON
ThesaurusID NLM (1994); DNA Relaxing Protein
Term UI T012965
Date10/13/1992
LexicalTag NON
ThesaurusID NLM (1994); DNA Topoisomerase
Term UI T012966
Date01/01/1999
LexicalTag ACX
ThesaurusID NLM (1978); DNA Untwisting Enzyme
Term UI T012970
Date10/13/1992
LexicalTag NON
ThesaurusID NLM (1994); DNA Type 1 Topoisomerase
Term UI T012968
Date06/08/1981
LexicalTag NON
ThesaurusID UNK (19XX); DNA Untwisting Enzymes
Term UI T012969
Date10/14/1992
LexicalTag NON
ThesaurusID NLM (1994); DNA Untwisting Proteins
Term UI T012971
Date10/21/1992
LexicalTag NON
ThesaurusID NLM (1994); DNA Untwisting Protein
Term UI T012972
Date10/13/1992
LexicalTag NON
ThesaurusID NLM (1994); Topoisomerase I
Term UI T012975
Date09/01/1983
LexicalTag NON
ThesaurusID UNK (19XX); Type I DNA Topoisomerase
Term UI T012976
Date10/21/1992
LexicalTag NON
ThesaurusID NLM (1994); DNA Topoisomerase I
Term UI T012967
Date04/06/1984
LexicalTag NON
ThesaurusID UNK (19XX)

DNA Topoisomerase III alpha Narrower

Concept UI: M000649950
Registry Numbers: 0
Terms: DNA Topoisomerase III alpha Preferred Term
Term UI T000958386
Date05/17/2019
LexicalTag NON
ThesaurusID NLM (2020); TOP3alpha
Term UI T000958387
Date05/17/2019
LexicalTag NON
ThesaurusID NLM (2020); TOPO IIIalpha
Term UI T000958388
Date05/17/2019
LexicalTag NON
ThesaurusID NLM (2020); Topoisomerase IIIalpha
Term UI T000958389
Date05/17/2019
LexicalTag NON
ThesaurusID NLM (2020)

DNA Topoisomerase III beta Narrower

DNA Topoisomerase III Narrower

Concept UI: M000649952
Registry Numbers: 0
Terms: DNA Topoisomerase III Preferred Term
Term UI T000958393
Date05/17/2019
LexicalTag NON
ThesaurusID NLM (2020); Topo III
Term UI T000958396
Date05/18/2019
LexicalTag NON
ThesaurusID NLM (2020); Topoisomerase III
Term UI T000958394
Date05/18/2019
LexicalTag NON
ThesaurusID NLM (2020); TOP3 Topoisomerase
Term UI T000958395
Date05/18/2019
LexicalTag NON
ThesaurusID NLM (2020)

DNA Topoisomerases, Type I MeSH Descriptor Data 2025